Using Human Neural Progenitor Cell Models to Conduct Large-Scale Drug Screens for Neurological and Psychiatric Diseases.

Using Human Neural Progenitor Cell Models to Conduct Large-Scale Drug Screens for Neurological and Psychiatric Diseases.
Methods Mol Biol. 2019;1942:79-88
Authors: Hunt JFVS, Li M, Zhao X, Bhattacharyya A
Abstract
High-throughput drug screen (HTS) has become a viable approach for new treatment discovery in human diseases. Advances in gene editing technology and human pluripotent stem cell differentiation techniques have expanded the capability of HTS to identify potential treatments for human diseases of the central nervous system. Here, we describe techniques to use a human patient-derived neural progenitor cell luciferase reporter line to screen a large small molecule library.
PMID: 30900177 [PubMed - indexed for MEDLINE]

Source: Mol Biol Cell - August 22, 2019 Category: Molecular Biology Authors: Hunt JFVS, Li M, Zhao X, Bhattacharyya A Tags: Methods Mol Biol Source Type: research