Baboon‐Like Syndrome in Children

We describe for the first time baboon syndrome in a child induced by a coinfection with Epstein‐Barr virus and cytomegalovirus.
Source: Pediatric Dermatology - Category: Dermatology Authors: Tags: Case Report Source Type: research

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Contributors : Jiabin Huang ; Denise Ohnezeit ; Nicole Fischer ; Ina A Stelzer ; Christopher Urbschat ; Petra C ArckSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusDuring mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) is largely unknown. We show that MMc induce a preferential differentiation of hematopoietic stem and progenitor cells towards myelopoiesis in bone marrow of fetal mice, and improves resilience against cytomegalovirus infection in neonates. In humans, low MMc counts in cor...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research
Conclusions: There may be a potential association between the gH2 genotype of CMV and infantile thrombocytopenia. PMID: 32479132 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
In this study, (iso)quinoline-artemisinin hybrids, obtained via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or organocatalyzed click reactions (in organic solvents or in the presence of water), were analyzed in vitro for the first time for their inhibitory activity against human cytomegalovirus (HCMV), as compared with their parent compounds and the reference drug ganciclovir. EC50 (HCMV) values were obtained in a range 0.22-1.20 µM, indicating highly potent antiviral properties in the absence of cytotoxic effects on normal cells (CC50>100 µM). The most active hybrid 1 (EC50 = 0.22 µM) is 25 ti...
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research
Contributor : Erik ProckoSeries Type : OtherOrganism : Homo sapiensA trimeric glycoprotein complex on the surface of human cytomegalovirus (CMV) binds to platelet-derived growth factor (PDGF) receptor α (PDGFRα) to mediate host cell recognition and fusion of the viral and cellular membranes. Soluble PDGFRα potently neutralizes CMV in tissue culture, and its potential use as an antiviral therapeutic has the benefit that any escape mutants will likely be attenuated. However, PDGFRα binds mult iple PDGF ligands in the human body as part of developmental programs in embryogenesis and continuing through ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Hematopoietic cell transplantation (HCT) is an established treatment for several hematologic and solid malignancies. Patients undergoing HCT have prolonged neutropenia after transplantation due to conditioning with high-dose chemotherapy with or without total body irradiation. Although gastrointestinal endoscopy is indicated for the diagnosis and treatment of HCT-related complications that can present during the engraftment period such as acute graft versus host disease, gastrointestinal cytomegalovirus infection, and hemorrhage, it is relatively contraindicated due to concern for translocation of enteric pathogens during the procedure.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstracts Source Type: research
In conclusion, UL33 facilitates cell-associated and cell-free spread of the clinical HCMV strain Merlin in fibroblast cultures.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Publication date: Available online 27 May 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Vivien R. Sutton, Christopher Andoniou, Michael G. Leeming, Colin M. House, Sally V. Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A. Trapani
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research
AbstractPurpose of ReviewThe aim of this report is to review the current literature regarding the diagnosis, treatment, management, and rehabilitation of congenital cytomegalovirus (cCMV) –associated sensorineural hearing loss (SNHL).Recent FindingsHearing-targeted CMV screening is successful in identifying cases of cCMV-related hearing loss. However, a significant number of children who develop cCMV-related SNHL may not be detected on newborn hearing screening, and it may be cost-effective to implement a universal CMV screening program. We also broadly review the management and audiologic rehabilitation of cCMV-asso...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research
Beyond HIV infection: neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases. Virus Res. 2020 May 29;:198040 Authors: Ellwanger JH, Kulmann-Leal B, Kaminski VL, Rodrigues AG, de Souza Bragatte MA, Chies JAB Abstract The interactions between chemokine receptors and their ligands may affect susceptibility to infectious diseases as well as their clinical manifestations. These interactions mediate both the traffic of inflammatory cells and virus-associated immune responses. In the context of viral infections, the human C-C chemokine receptor type 5 (CCR5) receives great attention from th...
Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research
The association between cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus, as assessed by serum immunoglobulin G, plays a role in neurodegeneration w...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
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