Amyloid cross-seeding raises new dimensions to understanding of amyloidogenesis mechanism.

Amyloid cross-seeding raises new dimensions to understanding of amyloidogenesis mechanism.
Ageing Res Rev. 2019 Aug 17;:100937
Authors: Chaudhuri P, Prajapati KP, Anand BG, Dubey K, Kar K
Abstract
Hallmarks of most of the amyloid pathologies are surprisingly found to be heterocomponent entities such as inclusions and plaques which contain diverse essential proteins and metabolites. Experimental evidences have already revealed the occurrence of coaggregation and cross-seeding during amyloid formation of several proteins and peptides, yielding multicomponent assemblies of amyloid nature. Further, research reports on the co-occurrence of more than one type of amyloid-linked pathologies in the same individual suggest the possible cross-talk among the disease related amyloidogenic protein species during their amyloid growth. In this review paper, we have tried to gain more insight into the process of co-aggregation and cross-seeding during amyloid aggregation of proteins, particularly focusing on their relevance to the pathogenesis of the protein misfolding diseases. Revelation of amyloid cross-seeding and coaggregation seems to open new dimensions in our mechanistic understanding of amyloidogenesis and such knowledge may possibly inspire better designing of anti-amyloid therapeutics.
PMID: 31430565 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - August 16, 2019 Category: Genetics & Stem Cells Authors: Chaudhuri P, Prajapati KP, Anand BG, Dubey K, Kar K Tags: Ageing Res Rev Source Type: research