Accidental and Unintentional Findings From the Midstream Clean-Catch Urine Contamination Study: Insights From Applying the Behavior Engineering Model

Over 2.6 million ED visits across the United States result in a primary diagnosis of urinary tract infection.1 While much attention has been paid to reducing blood culture contamination rates in the emergency department,2-9 a substantial gap remains in projects aimed at reducing contamination in clean-catch urine specimens obtained in the ED setting. Obtaining an adequate urine culture is clinically important to the care of several vulnerable patient groups, including patients with diabetes or compromised immune responses, those with high risk for subsequent urosepsis, previous antibiotic resistant infections, multiple antibiotic allergies and/or repeated infections, and older adults.
Source: Journal of Emergency Nursing: JEN - Category: Nursing Authors: Tags: Editorial Source Type: research

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In this study, a smartphone camera using an image-based colorimetric detection method was successfully developed for quantitative analysis of urine glucose. A horseradish peroxidase-hydrogen peroxide-3,3'5,5'-tetramethylbenzidine (HRP-H2O2-TMB) system was optimized for a reliable and gradual color fading process via a glucose oxidase (GOD) catalyzed oxidation reaction. The color changes of the peroxidase-H2O2 enzymatic reactions in the 96-well microplate were captured by a smartphone RGB camera with subsequent detection of red, green, and blue (RGB) intensities decreasing at each image pixel. The highly quantitative relati...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract This work presents a reliable analytical procedure combining micro-extraction by packed sorbent (MEPS) and ultra-high performance liquid chromatography-electrospray ionization tandem mass spectrometry to determine 8-iso prostaglandin F2α, 8-iso prostaglandin E2 and prostaglandin E2 in dried blood spots (DBSs). To reach this goal, we optimized a fast semi-automated MEPS procedure for the clean-up and pre-concentration of the analytes extracted from a single DBS (50 μL) by a 70:30 v/v methanol:water mixture. Limits of detection of about 20 pg mL-1, satisfactory recoveries (90-110%) and very g...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract MicroRNAs (miRNA) involve in regulating different physiological processes whose dysregulation is associated with a wide range of diseases including cancers, diabetes and cardiovascular problems. Herein, we report a direct, sensitive and highly selective detection assay for circulating microRNA (miRNA). This detection strategy employs magnetic nanoparticles as the reaction platform which can not only allow online pre-concentration and selective separation but also integrates ligation reaction with amplification to enhance the sensitivity of the detection assay. With the presence of the target miRNA, the lo...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Publication date: Available online 14 September 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Josep Moreno-RiusAbstractOpioid addiction has reached the epidemic status in the United States in recent years. A multitude of factors have contributed to an alarming increase in misuse and health issues related to these drugs. Although medications exist to treat some aspects of opioid addiction since long ago, relapse and fatality rates remain very high despite their long-term availability. Therefore, more research devoted to better understanding its neural substrates is needed to aid developing new treatment opti...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
ESOPHAGEAL CANCERS AND MODEL SYSTEMS. Trans Am Clin Climatol Assoc. 2019;130:266-271 Authors: Rustgi AK Abstract Gastrointestinal cancers are largely epithelial in nature and arise from the esophagus, stomach, pancreas, colorectum and liver. In aggregate, these cancers are the most common malignancies in the United States and worldwide, but suffer from poor outcomes in late stages. Our overall work aims to elucidate the following: 1) how normal epithelial cells become metaplastic and dysplastic; 2) how tumor cells invade and interact with activated fibroblasts and immune cells; and 3) how tumor cells d...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
SYNDROMES OF KETOSIS-PRONE DIABETES. Trans Am Clin Climatol Assoc. 2019;130:145-155 Authors: Balasubramanyam A Abstract Ketosis-prone diabetes (KPD) is a heterogeneous condition characterized by patients who present with diabetic ketoacidosis but lack the phenotype of autoimmune type 1 diabetes. Here I review progress in our understanding of KPD and its place in the expanding universe of "atypical diabetes." I focus on investigations of our collaborative research group at Baylor College of Medicine and the University of Washington using a longitudinally followed, heterogeneous, multiethnic co...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
Publication date: Available online 14 September 2019Source: Saudi Journal of Biological SciencesAuthor(s): Fuad Ameen, Shorouk A. Reda, Sahar A. El-Shatoury, Emad M. Riad, Mohamed E. Enany, Abdullah A. AlarfajAbstractDairy production is threatened by antibiotic resistant pathogens worldwide, and alternative solutions to treat mastitis are not available. The prevalence of antibiotic resistant strains is not well known in less developed countries. The prevalence of pathogenic bacteria and their resistance to 21 commercial antibiotics were studied in milk samples taken from 122 dairy cows suffering from the symptoms of mastit...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
CONCLUSION: The diabetic trained rats demonstrate a protective effect of resistance training on the serum lipid profile. PMID: 31517608 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
CONCLUSION: Our results show that under hyperglycemic condition, expression of genes involved in the miRNA maturation was significantly increased in HUVECs. Upregulation of these genes may have role in diabetic complications through the dysregulation of the miRNA expression. PMID: 31517606 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
CONCLUSIONS: To the best of our knowledge, this is the first report of spontaneous bleeding probably caused by Exenatide. The exact pathophysiology, by which the drug can cause spontaneous bleeding, is still not clear and has to be revealed. PMID: 31517602 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
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