Assessment of muscle involvement in patients with Duchenne muscular dystrophy via segmental multifrequency bioelectrical analysis

Duchenne muscular dystrophy (DMD) is a severe X-linked recessive degenerative disorder of the skeletal muscles that affects 1 in 3,500 male births. It is caused by a mutation in the dystrophin gene, resulting in progressive muscle damage and its replacement by fat and connective tissue. No effective treatments are currently available; however, a number of promising genetic strategies have emerged as potential therapies [1, 2], including stop-codon readthrough and exon-skipping with antisense oligonucleotides, with several treatments currently entering clinical trials.

Source: Neuromuscular Disorders - August 20, 2019 Category: Neurology Authors: Satoshi Kuru, Tomoka Uchiyama, Ayako Hattori, Takatoshi Sato, Terumi Murakami, Keiko Ishigaki, Takahiro Nakayama Source Type: research