On-treatment improvement of an emerging psychosomatic depressive disorder among salmonella carriers: a multicenter experience from Egypt

Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

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This study establishes RstAB as a major regulator of virulence and diverse cellular functions in P. damselae subsp. damselae. Introduction Two-component signal transduction systems enable bacteria to sense environmental stimuli and transfer this information across the cytoplasmic membrane to the cytoplasm (Stock et al., 2000). Such systems consist of a membrane-embedded protein kinase which acts as a sensory component, and its cognate response regulator, a cytoplasmic transcriptional factor. When the sensory component of the pair is stimulated by a specific signal, it autophosphorylates a histidine residue and then...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study was initiated to identify C. jejuni proteins that contribute to adaptation to the host cell environment and cellular invasion. We demonstrated that C. jejuni responds to INT 407 and Caco-2 cells in a similar fashion at the cellular and molecular levels. Active protein synthesis was found to be required for C. jejuni to maximally invade these host cells. Proteomic and transcriptomic approaches were then used to define the protein and gene expression profiles of C. jejuni co-cultured with cells. By focusing on those genes showing increased expression by C. jejuni when co-cultured with epithelial cells, we discover...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 26 February 2019Source: Journal of Microbiological MethodsAuthor(s): Daoyi Xi, Fuyi Jing, Qian Liu, Boyang CaoAbstractPlesiomonas shigelloides is widely associated with human diarrheal disease. Research on this pathogen has been hampered by the absence of an effective genetic manipulation system. In the present study, an efficient and precise conjugation transfer procedure, mediated by suicide vector pRE112 was used to overcome this limitation. The efficiency of generating double recombinants was average 74.3%, and the conjugation protocol may be applied to other P. shigelloides strains. ...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
Publication date: February 2019Source: Brain, Behavior, and Immunity, Volume 76, SupplementAuthor(s): S. Hulsken, L. Balter, S. Aldred, J. Veldhuijzen van Zanten, S. Higgs, J. BoschNegative processing biases towards valenced information are a hallmark of depression. We set out to test whether peripheral inflammation can induce such negative interpretation biases. Forty healthy adult men received Salmonella Typhi vaccination and placebo injections on two separate days, using a double-blind crossover design. Blood samples were taken at baseline, 5.5h and 8h post-injection. The participants completed the P1vital® Oxford E...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: February 2019Source: Brain, Behavior, and Immunity, Volume 76, SupplementAuthor(s): J.A. Bosch, L.J. Balter, S. Hulsken, M.T. Drayson, S. Aldred, J.J. Veldhuijzen van Zanten, J.E. RaymondThere is an established link between social isolation and poor health outcomes, although the exact mechanisms explaining this association remain unclear. Lonely individuals show an enhanced inflammatory response to acute stress, and in the present study we investigated if loneliness also predicts inflammatory responses to a standardized immune challenge (typhoid vaccination). Using a within-subjects crossover design (doub...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 6 May 2018Source: Brain, Behavior, and ImmunityAuthor(s): Leonie J.T. Balter, Sasha Hulsken, Sarah Aldred, Mark T. Drayson, Suzanne Higgs, Jet J.C.S. Veldhuijzen van Zanten, Jane E. Raymond, Jos A. BoschAbstractThe ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of ‘theory of mind’ (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
Publication date: Available online 6 May 2018Source: Brain, Behavior, and ImmunityAuthor(s): Leonie J.T. Balter, Sasha Hulsken, Sarah Aldred, Mark T. Drayson, Suzanne Higgs, Jet J.C.S. Veldhuijzen van Zanten, Jane E. Raymond, Jos A. BoschAbstractThe ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of ‘theory of mind’ (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Abstract The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of 'theory of mind' (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness, factors that could also account for temporary social impairment. Hence, an experimental inflammation manipulation was applied that avoided this confound, isolating effects of inflammation and social interaction. Forty healthy...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Publication date: Available online 6 May 2018 Source:Brain, Behavior, and Immunity Author(s): Leonie JT Balter, Sasha Hulsken, Sarah Aldred, Mark T Drayson, Suzanne Higgs, Jet JCS Veldhuijzen van Zanten, Jane E Raymond, Jos A Bosch The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of ‘theory of mind’ (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
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