T-cell transcriptional profiling and immunophenotyping uncover LAG3 as a potential significant target of immune modulation in multiple myeloma

Immunological aging is related to the development of cancer, but factors that impact this relationship are only partially understood. Several studies demonstrated that aging correlates with increased peripheral blood T lymphocyte (PBTL) expression of p16INK4a [1,2], a molecular marker associated with cellular senescence and irreversible cell cycle arrest [3]. PBTL p16INK4a levels not only increase with chronological age, but are influenced by physiologic stress caused by smoking, chemotherapy, and physical inactivity [3].

Source: Biology of Blood and Marrow Transplantation - August 20, 2019 Category: Hematology Authors: Fabienne Lucas, Michael Pennell, Ying Huang, Don M. Benson, Yvonne A. Efebera, Maria Chaudhry, Tiffany Hughes, Jennifer A. Woyach, John C. Byrd, Suohui Zhang, Desiree Jones, Xiangnan Guan, Christin E. Burd, Ashley E. Rosko Source Type: research