Peripheral blood hemopoietic stem cell mobilization regimens in POEMS syndrome: a retrospective study at two haematological Italian centres

POEMS syndrome is a rare paraneoplastic condition associated to an underlying plasmacellular dyscrasia. POEMS is the acronym referring to the main features of this syndrome: polyradicoloneuropathy, organomegaly, endocrinopathy, monoclonal plasma-cell disorder and skin changes [1 –3]. The use of alkylating agents and autologous peripheral blood stem cell transplantation (aPBSCT) seems to be the best strategy in eligible patients [4–8]. At present aPBSCT should be considered first-line therapy in young patients with POEMS syndrome, eligible for High-Dose Melphalan (HD-Mel ), in absence of organ dysfunction.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Brief article Source Type: research

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ConclusionThis retrospective analysis provides important information on the clinical characteristics of POEMS syndrome in Indian patients, which will help the clinician’s decision-making process.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Hepatic abnormalities in patients with lymphoproliferative disorders are common and can occur from direct infiltration by abnormal cells, bile duct obstruction, paraneoplastic syndrome, hemophagocytic syndrome, drug-induced liver injury, opportunistic infections, and reactivation of viral hepatitis. Hepatic involvement by lymphoma is often in association with systemic disease and rarely seen as a primary hepatic lymphoma. Vanishing bile duct syndrome is a well-known complication of Hodgkin disease. Antiviral prophylaxis for hepatitis B virus (HBV) reactivation is recommended for all HBsAg+  patients undergoing chemoth...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
Introduction. POEMS syndrome is a rare paraneoplastic condition associated to an underlying plasmacellular dyscrasia. The use of alkylating agents and autologous peripheral blood stem cell transplantation (aPBSCT) seem to be the best strategy.At present aPBSCT should be considered the first line therapy in young patients with POEMS, eligible for high-dose Melphalan (HD-Mel), in absence of organ dysfunction. The best protocol to collect PBSC in patients affected by POEMS remains to be defined, because of the disease rarity and the heterogeneity of published case series.We therefore decided to combine the case series of our ...
Source: Blood - Category: Hematology Authors: Tags: 711. Cell Collection and Processing Source Type: research
We describe 2 patients with unicentric Castleman disease complicated by paraneoplastic pemphigus and bronchiolitis obliterans. In addition to primary surgical resection for Castleman disease, we also used therapy from a treatment protocol used for bronchiolitis obliterans resulting from hematopoetic stem cell transplant (HSCT). We were able to treat the patients using intravenous immunoglobulin; rituximab; fluticasone, azithromycin, and monteleukast (FAM); and rosuvastatin therapy. One patient demonstrated a favorable response, while the other demonstrated minimal response to this therapy.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
The syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) is a rare disorder. It is considered paraneoplastic to a usually IgA λ-secreting monoclonal plasma cell dyscrasia.1 High-dose melphalan followed by autologous stem cell transplant (ASCT) is the standard of care in disseminated POEMS syndrome but can be associated with significant treatment-related morbidity and mortality.2 No paradigm exists for managing patients wh o experience relapse and those ineligible for ASCT.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Letter to the Editor Source Type: research
POEMS syndrome is a rare paraneoplastic disorder secondary to plasma cell dyscrasia. The acronym denotes the main disease characteristics, namely demyelinating polyneuropathy, organomegaly, endocrinopathy, λ-type M protein, and skin changes such as hypertrichosis, skin thickening, cherry angiomata, and hyperpigmentation [1]. Other important features include sclerotic bone lesions, extravascular fluid overload resulting in pleural effusions and/or ascites, papilledema, thrombocytosis, plasmacytomas, p ulmonary hypertension, multicentric Castleman disease, and elevated serum vascular endothelial growth factor (VEGF) [2-4].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Abstract POEMS syndrome is a rare paraneoplastic condition, with a poorly understood pathogenesis. High dose chemotherapy followed by autologous stem cell transplantation (ASCT) has been reported to be an effective therapeutic option for patients with good performance status. Here, we review the role of ASCT for POEMS syndrome and discuss indications together with advantages and disadvantages, and related issues such lenalidomide given before or after ASCT, VEGF levels as a marker of disease, and different regimens for stem cell mobilization.
Source: Hematological Oncology - Category: Hematology Authors: Tags: REVIEW Source Type: research
Abstract Disease OverviewPOEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Diagnoses are often delayed because the syndrome is rare and can be mistaken for other neurologic disorders, most commonly chronic inflammatory demyelinating polyrad...
Source: American Journal of Hematology - Category: Hematology Authors: Tags: ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES: A CONTINUING MEDICAL EDUCATION SERIES Source Type: research
Conclusions:Better recognition and management of different presentations of various paraneoplastic syndromes represent new challenges in the management of patients with malignancies. Further studies in paraneoplastic syndromes are needed.Disclosure: Dr. G. Prieto has nothing to disclose. Dr. Giglio has nothing to disclose. Dr. Puduvalli has received personal compensation for activities with Novartis and Genentech as a scientific advisory board member. Dr. Pudavalli has received research support from Genentech and Merck.
Source: Neurology - Category: Neurology Authors: Tags: Neurologic Complications of Cancer Source Type: research
Opinion statementBiotherapy represents an innovative therapeutic approach that includes immunotherapy (vaccines, apheresis, and antibodies); gene therapy; and stem cell transplants. Their development helps to cross the bridge from bench to bedside and brings new hope of a cure for severe diseases in different fields of medicine. In neurology, a growing range of applications is being developed for these medications. Valuable results are now available in the field of autoimmunity, neuro-oncology, paraneoplastic manifestations, and neurodegenerative disorders. In this review, we examine the current and future applications of ...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
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