Peripheral blood hemopoietic stem cell mobilization regimens in POEMS syndrome: a retrospective study at two haematological Italian centres

POEMS syndrome is a rare paraneoplastic condition associated to an underlying plasmacellular dyscrasia. POEMS is the acronym referring to the main features of this syndrome: polyradicoloneuropathy, organomegaly, endocrinopathy, monoclonal plasma-cell disorder and skin changes [1 –3]. The use of alkylating agents and autologous peripheral blood stem cell transplantation (aPBSCT) seems to be the best strategy in eligible patients [4–8]. At present aPBSCT should be considered first-line therapy in young patients with POEMS syndrome, eligible for High-Dose Melphalan (HD-Mel ), in absence of organ dysfunction.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Brief article Source Type: research