Single-Dose Pharmacokinetics and Tolerability of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Subjects with Severe Renal Function Impairment

ConclusionsBased on these single-dose results, subjects with mild, moderate, or severe renal function can be included in clinical studies without the need for dose adjustment.

Source: Clinical Drug Investigation - August 20, 2019 Category: Drugs & Pharmacology Source Type: research