Fatal anaphylactic shock in a patient undergoing hemodialysis via a polyurethane catheter.

Fatal anaphylactic shock in a patient undergoing hemodialysis via a polyurethane catheter. Clin Nephrol. 2019 Aug 20;: Authors: Fülöp T, Elliott AB, Jenssen F, Ullian ME, Herberth J PMID: 31426906 [PubMed - as supplied by publisher]
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research

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Abstract Stinging accidents involving wasp venom are a notable cause of acute kidney injury (AKI) in Asia. However, very little attention has been paid to the understanding of the mechanisms involved in this type of AKI. The aims of this review are to explore the evidence for the mechanisms and the therapeutic role of renal replacement therapy of wasp venom and AKI. A systematic literature search was conducted using PubMed for the association among wasp venom and AKI. Wasp venom is a complex mixture of biologically active components, including enzymes, amines, and peptides. Wasp venom may induce local anaphylaxis ...
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research
Abstract Iron deficiency is a significant health problem across the world. While many patients benefit from oral iron supplements, some, including those on hemodialysis require intravenous iron therapy to maintain adequate iron levels. Until recently, all iron compounds suitable for parenteral administration were colloidal iron-carbohydrate conjugates that require uptake and processing by macrophages. These compounds are associated with variable risk of anaphylaxis, oxidative stress, and inflammation, depending on their physicochemical characteristics. Ferric pyrophosphate citrate (FPC) is a novel iron compound th...
Source: Biometals - Category: Biochemistry Authors: Tags: Biometals Source Type: research
Authors: Shindo M, Ookawara S, Kitano T, Ishii H, Miyazawa H, Ito K, Ueda Y, Hirai K, Hoshino T, Morishita Y PMID: 30220495 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
CONCLUSION: The majority of thrombosed accesses can be successfully treated, maintaining its long-term patency. The need of repeated intervention is frequent. PMID: 30207374 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Abstract Several cases of patients with anaphylactic or systemic hypersensitivity reactions to polysulfone (PS) hemodialysis (HD) membranes and tolerance to cellulose triacetate (CTA) membranes have recently been reported. To investigate the mechanisms involved in PS hypersensitivity, basophil, T cell, and complement activation were analyzed in acute‐phase samples from two patients with systemic reactions to PS‐based membranes. Basophil and T cell activation, as well as higher serum tryptase levels were detected in acute‐phase samples compared with basal levels. Complement levels (C3 and C4) were decreased in acute...
Source: Artificial Organs - Category: Transplant Surgery Authors: Tags: Main Text Source Type: research
CONCLUSION: Although hypersensitivity reactions are uncommon in patients receiving hemodialysis, they can be life-threatening. Moreover, considering the large prevalence of the end-stage renal disease population, the implications of such reactions are enormous. Most reactions are pseudoallergic and not mediated by immunoglobulin E. The multiplicity of potential exposures and the complexity of the environment to which patients on dialysis are exposed make it challenging to identify the precise cause of these reactions. Great diligence is needed to investigate hypersensitivity reactions to avoid recurrence in this high-risk ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Abstract Anemia in chronic kidney disease is common and iron deficiency is an important cause. To repair iron‐deficiency anemia, replacement of iron is needed. Iron can be replaced either by the oral route or by the intravenous route. In a meta‐analysis, 5 of the 6 trials were short‐term, 1 to 3 months, and compared to oral iron, the mean increase in hemoglobin with intravenous iron was only 0.31 g/dL. However, one of the studies included in this meta‐analysis was 6 months long and had a mean decline in hemoglobin of 0.52 g/dL associated with intravenous iron administration. Given the short duration of most of the ...
Source: Hemodialysis International - Category: Hematology Authors: Tags: Supplement Article Source Type: research
Abstract Anemia is common among patients with chronic kidney disease (CKD) and it is managed primarily with erythropoiesis‐stimulating agents (ESA) and iron therapy. Following concerns around ESA therapy and economic constraints, IV iron is more and more administered worldwide. Several guidelines or position papers, which give indications on iron therapy in CKD patients, have been issued in Nephrology. Unfortunately, the field is characterized by a lack of evidence. As a result, the recommendations/suggestions are not uniform. There is general consensus to prescribe iron therapy to patients who are clearly iron deficient...
Source: Hemodialysis International - Category: Hematology Authors: Tags: Supplement Article Source Type: research
CONCLUSION: This study provides evidence that iron dextran and ferric carboxymaltose have complement-activating capacities in-vitro, and hypersensitivity reactions to these drugs could be CARPA-mediated. PMID: 27889746 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
Conclusion: This study provides evidence that iron dextran and ferric carboxymaltose have complement-activating capacities in-vitro, and hypersensitivity reactions to these drugs could be CARPA-mediated.Am J Nephrol 2017;45:49-59
Source: American Journal of Nephrology - Category: Neurology Source Type: research
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