Impact of Atrial Arrhythmia on Survival in Adults with Tetralogy of Fallot
ConclusionsAtrial fibrillation, but not atrial flutter, was associated with reduced survival in our repaired TOF cohort. Further studies are required to determine if more aggressive antiarrhythmic therapy will improve survival in patients with atrial fibrillation.
ConclusionThe overall estimated incidence of AF and recurrent AF during pregnancy is as high as 2.2% and 39.2%, respectively. AF during pregnancy may result in poor maternal and fetal outcomes.
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Publication date: Available online 4 September 2019Source: Pharmacological ResearchAuthor(s): Enrico Paolini, Giulia Stronati, Federico Guerra, Alessandro CapucciAbstractOver the last 35 years, flecainide proved itself one of the most commonly used arrhythmic drugs, expanding its original indication for ventricular arrhythmias and results nowadays as the cornerstone of the rhythm control strategy in atrial fibrillation management of patients without structural heart disease. While the increased mortality associated with flecainide in the Cardiac Arrhythmia Suppression Trial (CAST) still casts his shadow over flecainide cli...
Conclusion: Many patients with an LMNA mutation have neurologic symptoms by their 30s and develop progressive cardiac manifestations during the next decade. A substantial proportion of these patients will have life-threatening neurologic or cardiologic conditions. Primary Funding Source: None. PMID: 31476771 [PubMed - as supplied by publisher]
In conclusion HCN4-P883R may increase ectopic trigger and maintenance of AF by shifting the activation voltage of If to more positive potentials and producing higher current density. Together with the common KCNE1 variant S38G, previously proposed as a genetic modifier of AF, HCN4-P883R may provide a substrate for the development of AF and TIC. PMID: 31481236 [PubMed - as supplied by publisher]
Hypertension is the most common cardiovascular risk factor and underlies heart failure, coronary artery disease, stroke, and chronic kidney disease. Hypertensive heart disease can manifest as cardiac arrhythmias. Supraventricular and ventricular arrhythmias may occur in the hypertensive patients. Atrial fibrillation and hypertension contribute to an increased risk of stroke. Some antihypertensive drugs predispose to electrolyte abnormalities, which may result in atrial and ventricular arrhythmias. A multipronged strategy involving appropriate screening, aggressive lifestyle modifications, and optimal pharmacotherapy can re...
ConclusionsIn patients with HCM undergoing AF ablation, QTc prolongation, specifically>448 ms, and presence of fQRS are independent risk factors for arrhythmia recurrence at follow ‐up. The combination of these two parameters has greater predictive value and would help to identify patients who are at the highest risk of procedural failure.This article is protected by copyright. All rights reserved.
CONCLUSIONS: C allele and CC genotype of rs4968309 inMYL4were associated with AF onset and recurrence. Moreover, the A allele of rs1515751 had a significant association with AF onset. The polymorphisms ofMYL4can predict AF onset and prognosis after ablation in AF patients without structural heart disease. PMID: 31406021 [PubMed - as supplied by publisher]
CONCLUSIONS: Only one third of adult residents of Warsaw had normal ECG, and about a half of both young and asymptomatic individuals. The most often observed ECG abnormalities in men were intra-ventricular conduction disturbances, and ST segment depression and negative T wave changes in case of women. Atrial fibrillation was the most prevalent arrhythmia. We did not found statistically significant time trends for repolarization changes, conduction disturbances and arrhythmia. PMID: 31354161 [PubMed - as supplied by publisher]
In conclusion, e-noise is a potential danger in our world, and further studies are needed of its effects on mechanisms of aging, disease, and human health.