ASAP Codoping Enhanced Radioluminescence of Nanoscintillators for X-ray-Activated Synergistic Cancer Therapy and Prognosis Using Metabolomics

ACS NanoDOI: 10.1021/acsnano.9b04213
Source: ACS Nano - Category: Nanotechnology Authors: Source Type: research

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Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Weiwei Zeng, Hanjie Zhang, Yimin Deng, Aiting Jiang, Xiaoyan Bao, Minqi Guo, Zimu Li, Meiying Wu, Xiaoyuan Ji, Xiaowei Zeng, Lin MeiAbstractPhotonic therapy (e.g., photodynamic therapy (PDT) and photothermal therapy (PTT)), features easy handling, good targeting, high curative effect and lower side effects compared to other treatments, thus showing considerable potential in cancer treatment. However, adverse tumor microenvironment, low light conversion efficiency, and inherent toxicity of photonic agents limit their further application ...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
In this study, we design and synthesize a hybrid nanoplatform (HNP) that is made of photothermal nanomaterials, gold nanostars, and glycopolymer that is thermoresponsive and contains glucose and galactose. The glucose groups can specifically recognize Concanavalin A (ConA), being cytotoxic to hepatoma (HepG2) cells, and the galactose groups can target asialoglycoprotein receptor. Thus, a HNP-ConA system with synergistic effects for photothermal therapy of HepG2 Cells is formed. It is found that the synthesized HNP has excellent colloidal stability, and exhibits high photothermal conversion efficiency (50.5%) and binding ef...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Qiaojuan Jia, Zhenzhen Li, Chuanpan Guo, Xiaoyu Huang, Mengmeng Kang, Yingpan Song, Linghao He, Nan Zhou, Minghua Wang, Zhihong Zhang, Guodong Fu, Miao DuAbstractA novel drug nanocarrier system based on bimetallic NiCo Prussian blue analogue (NiCo-PBA) was constructed for targeted anticancer drug delivery and cancer therapy. Rare earth Tb3+ ion was doped in NiCo-PBA to prepare a complex with strong fluorescence performance (represented by NiCo-PBA@Tb3+). The NiCo-PBA@Tb3+ complex was functionalized with poly(ethyleneglycol)- dimethacryl...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 22 February 2020Source: Life SciencesAuthor(s): Maryam Ezzati, Bahman Yousefi, Kobra Velaei, Amin SafaAbstractBreast cancer is one of the well-known malignant tumors among women. In spite of attempts to classifying breast cancer according to its histological and molecular properties, it is almost considered as a dilemma in treatment. Nowadays, public and medical attentions have primary focused on foods with anti-cancer properties to alleviate the cancer problems. Flavonoid components such as Quercetin (Qu) as dietary substances with high attention of ordinary people might provide potentia...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 21 February 2020Source: PolymerAuthor(s): Inès Hamouda, Cédric Labay, Maria Pau Ginebra, Erwan Nicol, Cristina CanalAbstractAtmospheric pressure plasma jets (APPJ) have great potential in wound healing, bacterial disinfection and in cancer therapy. Recent studies pointed out that hydrogels can be used as screens during APPJ treatment, or even be used as reservoirs for reactive oxygen and nitrogen species generated by APPJ in liquids. Thus, novel applications are emerging for hydrogels which deserve fundamental exploration of the possible modifications undergone by the polyme...
Source: Polymer - Category: Chemistry Source Type: research
Publication date: Available online 22 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Andrea BUSNELLI, Amerigo VITAGLIANO, Laura MENSI, Stefano ACERBONI, Alessandro BULFONI, Francesca FILIPPI, Edgardo SOMIGLIANAAbstractSeveral epidemiological studies investigated the effects of cancer therapies on fertility. However, conflicting data have been reported.The present systematic review and meta-analysis aims to determine the chances of childbirth in women survived from different types of cancer.We systematically searched Pubmed, MEDLINE, Embase and Scopus, from database inception to July 17, 2019, for published ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionsThe significant association between both objective and subjective FT and HRQoL highlights the importance of reducing FT among urologic cancer patients. Subjective FT was found to have a greater negative impact on HRQoL.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
We describe the supportive medications used by treatment-na ïve lung cancer patients and assess their association with PROs from MD Anderson Symptom Inventory (MDASI).MethodsTreatment-na ïve lung cancer patients who completed PROs from MDASI at the initial visit to MD Anderson Cancer Center were included. Medications from the initial visit were abstracted from the electronic medical records system and categorized into therapeutic classes based on U.S. Pharmacopeia v7.0. A chi-squar e or Mann-WhitneyU test was conducted as appropriate.ResultsAmong 459 patients, ~  50% took any analgesics and 25% were on opi...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Double ‐faced (Janus) gold‐iron oxide nanoparticles combine magnetic and plasmonic features as smart multifunctional platforms for theranostics nanomedicine. Herein, they are proved as efficient therapeutic nanoheaters under both magnetic hyperthermia (MHT) and photothermia (PTT) procedures. Thanks to the magnetic core, PTT can be improved on‐site upon systemic administration and magnetic guiding, leading to tumor growth inhibition. AbstractProgress of thermal tumor therapies and their translation into clinical practice are limited by insufficient nanoparticle concentration to release therapeutic heating at the tumor...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Publication date: June 2020Source: Nano Today, Volume 32Author(s): Fei Gong, Nailin Yang, Xianwen Wang, Qi Zhao, Qian Chen, Zhuang Liu, Liang ChengAbstractThe design and development of tumor microenvironment (TME)-responsive intelligent nanoplatforms have attracted increasing interest to enhance the therapeutic effects of drugs, due to their potential to address some significant therapeutic issues, such as unsatisfying therapeutic outcomes and serious side effects. In this review, we mainly summarize the strategies used to construct these nanoplatforms based on characteristic factors present at high levels in the TME, incl...
Source: Nano Today - Category: Nanotechnology Source Type: research
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