Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

Zhou et  al. show that the m6A reader protein hnRNPG interacts with m6A-modified nascent pre-mRNA and the phosphorylated C-terminal domain of RNA polymerase II to regulate alternative splicing. These interactions depend on an RGG region in the low-complexity region of hnRNPG.

Source: Molecular Cell - August 20, 2019 Category: Cytology Authors: Katherine I. Zhou, Hailing Shi, Ruitu Lyu, Adam C. Wylder, Żaneta Matuszek, Jessica N. Pan, Chuan He, Marc Parisien, Tao Pan Tags: Article Source Type: research