SOX18 Affects Cell Viability, Migration, Invasiveness, and Apoptosis in Hepatocellular Carcinoma (HCC) Cells by Participating in Epithelial-to-Mesenchymal Transition (EMT) Progression and Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR).

CONCLUSIONS SOX18 downregulation in HCC cells suppressed cell viability and metastasis, induced cell apoptosis and hindered the occurrence and progression of tumor cells by participating in the EMT process and regulating the autophagy signaling pathway AMPK/mTOR. PMID: 31427562 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

Related Links:

Publication date: Available online 20 September 2019Source: Biocybernetics and Biomedical EngineeringAuthor(s): Tasleem Kausar, MingJiang Wang, Muhammad Idrees, Yun LuAbstractAmong the predominant cancers, breast cancer is one of the main causes of cancer deaths impacting women worldwide. However, breast cancer classification is challenging due to numerous morphological and textural variations that appeared in intra-class images. Also, the direct processing of high resolution histological images is uneconomical in terms of GPU memory. In the present study, we have proposed a new approach for breast histopathological image ...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
This study was aimed at detecting NRAS G12D and NRAS G13C mutant genes among apparently healthy and haematologic malignant individuals, and to explore their association with some clinical and demographic factors as well as disease status and progression. A total of 200 cfDNAs, 100 each from haematologic malignant patients and blood donors, respectively, were analyzed for the presence of NRAS gene mutations in codons 12 and 13. These mutations were tested using multiplex allele-specific PCR (AS-PCR). The mutations were detected by selective amplification using mutation-specific synthetic oligonucleotides. NRAS G12D and NRAS...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
Publication date: Available online 20 September 2019Source: Biosensors and BioelectronicsAuthor(s): Zhen Rong, Zikun Bai, Jianing Li, Hao Tang, Tianyi Shen, Qiong Wang, Chongwen Wang, Rui Xiao, Shengqi WangAbstractSimultaneous detection of free and complexed prostate-specific antigen (f-PSA and c-PSA) is critical to the prostate cancer (PCa) diagnostic accuracy for clinical samples with PSA values in the diagnostic gray zone between 4 and 10 ng mL−1. Herein, red and green magnetic-quantum dot nanobeads (MQBs) with superior magnetic property and high luminescence were fabricated via polyethyleneimine-intermediated...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: 15 January 2020Source: Journal of Molecular Structure, Volume 1200Author(s): Xingxing Gao, Guidong Gong, Zhonghui Zhang, Guoyuan Du, Yuan Cao, Gang ZhaoAbstractThe cyclopalladated compound (−)-(Sp,R,R,Sp)-3 was obtained by the reaction between acetylferrocene and chiral amines (+)-R-1, followed by palladium acetate and sodium nitrite. (−)-(Sp,R,R,Sp)-3 was characterized by 1H, 13C NMR and ESI-MS. The absolute configuration of the compound (−)-(Sp,R,R,Sp)-3 is determinated by single crystal diffraction. It is found that the compound (−)-(Sp,R,R,Sp)-3 (IC50 = 0.15 μM, 0.49...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 20 September 2019Source: Chemico-Biological InteractionsAuthor(s): Alina Hanf, Matthias Oelze, Adrian Manea, Huige Li, Thomas Münzel, Andreas DaiberAbstractThe anthracycline doxorubicin (DOX) is widely used in cancer therapy with the limitation of cardiotoxicity leading to the development of congestive heart failure. DOX-induced oxidative stress and changes of the phosphoproteome as well as epigenome were described but the exact mechanisms of the adverse long-term effects are still elusive. Here, we tested the impact of DOX treatment on cell death, oxidative stress parameters and exp...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: September 2019Source: European Urology Supplements, Volume 18, Issue 6Author(s): A. Aydin, C. Kahir, M. Patel, C. Allen, P. Dasgupta
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: September 2019Source: European Urology Supplements, Volume 18, Issue 6Author(s): E. Koseoglu, A.E. Canda, B. Cil, M.C. Kiremit, K. Tarim, H. Nuhoglu, Y. Kordan, M.D. Balbay, T. Esen
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: September 2019Source: European Urology Supplements, Volume 18, Issue 6Author(s): S. Cakmak, E. Koseoglu, K. Tarim, A.E. Canda, M.C. Kiremit, Y. Kordan, A. Armutlu, D. Ertoy, M.D. Balbay, T. Esen
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: September 2019Source: European Urology Supplements, Volume 18, Issue 6Author(s): Y. Raskin, M. Joris, G. Devos, V. Caldéron Plazarte, W. Everaerts, S. Joniau
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Conclusion MTDH is pro-oncogenic factor playing multifaceted and diverse roles in cancer progression. Its association and central role in regulating signaling pathways such a MAPK, wnt/β-catenin, PI3K/AkT, NF-κβ pathways in various cancers shows that it plays a vital role in metastasis. MTDH contribution to chemo and radiotherapy resistance provides a new direction for the development of anticancer therapeutics. Multiple mechanisms converge to promote expression of MTDH in cancers. Further studies are therefore warranted to determine whether the elevated MTDH expression has prognostic value for development...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
More News: Biomedical Science | Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Ductal Carcinoma | Epithelial Cancer | Genetics | Hepatocellular Carcinoma | Liver Cancer | Lung Cancer | Molecular Biology | Non-Small Cell Lung Cancer | Ovarian Cancer | Ovaries | Research | Science | Study