Many faces of posttransplant infections

A 39-year-old male, live-related renal transplant recipient with stable graft function presented with multiple painless, non-itchy, papular lesions over the midback region. Three months later, these lesions became multiple abscesses with pus exudation (Figure  1). The patient had a history of injury to his midback from the sharp edge of cement stairs, which caused an abrasion. He had received a thymoglobulin induction and was on prednisolone, tacrolimus, and azathioprine. The microscopic examination of KOH mount of pus revealed multiple, septate, branch ing, brown-pigmented hyphae with thick-walled vesicular swellings (Supplementary Figure S1) suggestive of phaeohyphomycosis.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research

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AbstractPurposeHematopoietic progenitor cell transplantation (HSCT) is a procedure used in different hematological diseases as part of the curative treatment, so the investigators propose a system of conditioning of reduced intensity based on total lymphoid irradiation (TLI) as an alternative to the classic total body irradiation (TBI) followed by haploidentical transplantation in patients compatible with a single HLA haplotype, as an alternative to patients who do not have an HLA compatible donor.Materials and methodsA cohort of 25 patients with hematological disease underwent haploidentical HSCT from February 2015 to May...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
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This study aimed to elucidate the clinical relevance of immune-related gene expression in peripheral blood of kidney transplant recipients. The expression levels of fourteen key molecules (Foxp3, CTLA-4, CCR7, TGF-β, IGLL-1, IL-10, ITCH, CBLB, Bcl-6, CXCR5, granzyme B, CIITA, Baff, TOAG-1/TCAIM) related to regulatory/cytotoxic function of immune cells were compared in 93 patients, which were divided into Groups A (clinical cAMR with dn DSA, n=16), B (subclinical cAMR with dn DSA, n=17), C (negative cAMR with dn DSA, n=21) and D (stable function without dn DSA, n=39). CIITA mRNA expression levels in groups B and C were...
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research
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