Statin, anesthesia, and renal dysfunction after open repair of abdominal aortic aneurysms

We read with great interest the study by O'Donnell et  al,1 which investigated the risk factors of postoperative renal dysfunction after open repair of abdominal aortic aneurysm (AAA) in a large retrospective cohort.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research

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We thank Drs Yoon and Kim for their interest in our study and the higher risk for acute kidney injury (AKI) after open repair of juxtarenal abdominal aortic aneurysms in patients taking statins preoperatively. Our understanding of the interaction between statins and postoperative renal function is constantly evolving, as both observational and randomized trials have met with mixed results. Importantly, previous studies showed that initiating statins in the perioperative period was associated with higher rates of postoperative AKI, whereas long-term statin use was associated with lower risk of renal complications.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
n S Abstract Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammatory cell infiltration. The present extended immunohistochemistry study aimed to characterize inflammation in AAA and aortic control samples. In specific, the composition of the infiltrating immune cells and the expression of five inflammasome components in these immune cells were evaluated, in order to characterize their role in AAA development. A total of 104 biopsies from 48 AAA patients and 40 healthy specimens from organ donors were evaluated for their grade of inflammation. Infiltrating leukocytes were characterized by specif...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
CONCLUSION: This study has found that knockdown of miR-33-5p induced ABCA1 expression and promoted inflammatory cytokines and cholesterol efflux likely via activating the PI3K/Akt signaling pathway. PMID: 31170866 [PubMed - as supplied by publisher]
Source: Perfusion - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Perfusion Source Type: research
Authors: Mirjanic-Azaric, Bosa / Vasic, Novak / Cerne, Darko / Kos, Janko / Bogavac-Stanojevic, Natasa
Source: Journal of Medical Biochemistry - Category: Biochemistry Source Type: research
Abstract: Statins have been suggested in previous studies to play a protective role in experimental cerebral aneurysm (CA) models; however, no evidence supports that the application of statins can protect against aneurysm rupture in humans, and the risks of lipid levels and aneurysms remain unknown. Therefore, this meta-analysis aimed to summarize and update the epidemiological evidence to systematically assess the relationships of statin therapy and hyperlipidemia with the incidence, rupture, postrepair mortality, and all-cause mortality of abdominal aortic aneurysm (AAA) and CA. Related studies were initially retrieved...
Source: Journal of Cardiovascular Pharmacology - Category: Cardiology Tags: Original Article Source Type: research
This study is a retrospective review of Cochrane CENTRAL database, MEDLINE, and Embase through June 15, 2018.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Patients with abdominal aortic aneurysms should be taking statins regardless of whether you are observing them or planning to repair them Source Type: research
Source: World Journal of Surgery - Category: Surgery Source Type: research
Authors: Mirjanic-Azaric, Bosa / Vasic, Novak / Cerne, Darko / Kos, Janko / Bogavac-Stanojevic, Natasa
Source: Journal of Medical Biochemistry - Category: Biochemistry Source Type: research
Adherence to antiplatelet and statin therapy in participants diagnosed with abdominal aortic aneurysm (AAA) or peripheral arterial disease (PAD) was examined in a vascular screening trial.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
CONCLUSION: In a vascular screening trial, six of every 10 non-users initiated preventive treatment; among these, the adherence rate was 57-60%. Among users at baseline, the five year adherence to antiplatelet and statin treatment exceeded 80%. The effectiveness of screening initiatives might be improved by measures to improve the fulfilment of preventive medication. PMID: 30393062 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Tags: Eur J Vasc Endovasc Surg Source Type: research
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