Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency

Arteriovenous fistulas (AVFs) are the most common access created for hemodialysis, but approximately 40% fail to mature, suggesting a clinical need. In a mouse model, reduced Akt1 expression reduces AVF wall thickness and diameter. We hypothesized that inhibition of Akt1-mTORC1 axis alters venous remodeling associated with failure of AVF.

Source: Journal of Vascular Surgery - August 21, 2019 Category: Surgery Authors: Arash Fereydooni, Xiangjiang Guo, Jolanta Gorecka, Toshihiko Isaji, Shun Ono, Ryosuke Taniguchi, Naiem Nassiri, Alan Dardik Tags: Abstract from the 2019 New England Society for Vascular Surgery Annual Meeting Source Type: research