Palmitate-TLR4 Signaling Regulates Epigenetic Modifications in Macrophages and Impairs Diabetic Wound Healing

Macrophage (M ϕ) plasticity allows transition of Mϕs from an inflammatory to a reparative phenotype and is critical for wound healing. In pathologic conditions, such as type 2 diabetes (T2D), wounds fail to heal because of impaired resolution of inflammation. Although the mechanisms responsible for persistent T 2D inflammation are unknown, growing evidence indicates that the Toll-like receptor (TLR) 4 and saturated fatty acids (SFAs) drive Mϕ-mediated inflammation. Given the excess SFAs in T2D, we hypothesized that SFAs induce epigenetic alterations in wound Mϕs and drive Mϕ inflammation that impairs di abetic wound healing.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2019 Midwestern Vascular Surgical Society Annual Meeting Source Type: research