Effect of the lymphovascular plugging metastasis pattern in extramammary Paget disease on identifying metastatic lesions by imaging tests: An autopsy case series.

Effect of the lymphovascular plugging metastasis pattern in extramammary Paget disease on identifying metastatic lesions by imaging tests: An autopsy case series. Br J Dermatol. 2019 Aug 16;: Authors: Maeda T, Yoshino K, Nagai K, Oaku S, Kato M, Hiura A, Uehara J, Fujisawa Y Abstract The prognosis of extramammary Paget disease (EMPD) is favourable if tumour cells are localised to the epidermis1 . However, patients with dermal and lymphatic invasion are at risk of metastasis, which is associated with poorer prognosis as no effective systemic therapy has been established2-4 . Patients with advanced EMPD present with characteristic metastatic patterns, such as underpants-distribution erythema and severe lymphoedema of the lower extremities resulting from lymphatic obstruction. PMID: 31420863 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research