Safety and Preliminary Efficacy of OBT076 in Recurrent/Metastatic CD205+ Solid Tumors and HER2-neg Breast Cancer

Conditions:   Breast Cancer;   Solid Tumor Intervention:   Drug: OBT076, a CD205-directed antibody-drug conjugate Sponsor:   Oxford BioTherapeutics Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Yu-Hui Zhou, Yang Liu, Wei Zhang, Chao Liu, Jian-Jun He, Xiao-Jiang TangABSTRACTBackgroundChemotherapy is the predominant treatment option for patients with breast cancer. Selection of patients according to biomarker will improve chemotherapy efficacy. In the present study, we examined the relations of the expression of candidate genes and 21-recurrence score (RS) results to patients’ demographic characteristics, histopathological factors, and outcomes.MethodsA total of 146 patients were enrolled in this study. The...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
A causal link between Human Papillomavirus (HPV) and breast cancer (BC) remains controversial. In spite of this, the observation that HPV DNA is over-represented in the Triple Negative (TN) BC has been reported. Here we remark the high prevalence of HPV DNA (44.4%) in aggressive BC subtypes (TN and HER2+) in a population of 273 Italian women and we convey the presence of HPV DNA in the epithelial and stromal compartments by in situ hybridization. As previously reported, we also found that serum derived-extracellular vesicles (EVs) from BC affected patients contain HPV DNA. Interestingly, in one TNBC patient, the same HPV D...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Advanced Breast Carcinoma;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJCC v8;   Anatomic Stage IIIB Breast Cancer AJCC v8;   Anatomic Stage IIIC Breast Cancer AJCC v8;   Anatomic Stage IV Breast Cancer AJCC v8;   Germlin e BRCA1 Gene Mutation;   Germline BRCA2 Gene Mutation;   HER2/Neu Negative;   Metastatic Breast Carcin...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Anatomic Stage IV Breast Cancer AJCC v8;   Breast Carcinoma Metastatic in the Bone;   HER2/Neu Negative;   Metastatic Breast Carcinoma;   Metastatic Triple-Negative Breast Carcinoma;   Prognostic Stage IV Breast Cancer AJCC v8 Interventions:   Drug: Paclitaxel;   Radiation: Radium Ra 223 Dichloride Sponsor:   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Advanced Breast Carcinoma;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJCC v8;   Anatomic Stage IIIB Breast Cancer AJCC v8;   Anatomic Stage IIIC Breast Cancer AJCC v8;   Anatomic Stage IV Breast Cancer AJCC v8;   Germlin e BRCA1 Gene Mutation;   Germline BRCA2 Gene Mutation;   HER2/Neu Negative;   Metastatic Breast Carcin...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: 2019Source: European Journal of Radiology Open, Volume 6Author(s): Taiyo L. Harada, Kazuaki Nakashima, Takayoshi Uematsu, Takashi Sugino, Seiichirou Nishimura, Kaoru Takahashi, Yukiko Tadokoro, Tomomi Hayashi, Junichiro Watanabe, Shogo NakamotoAbstractA 63-year-old woman was referred to our hospital for breast cancer treatment. She had a large HER2-positive breast tumor on her left breast, and received neoadjuvant chemotherapy. After treatment, a shrunk spiculated mass with calcification-like high density was detected on mammography, and MRI revealed a large strong susceptibility artifact. Surgical specim...
Source: European Journal of Radiology Open - Category: Radiology Source Type: research
AbstractPurposeLiterature on the separate effects of physical activities (PA) on risk of breast cancer (BC) sub-types is heterogeneous. We investigated domain-specific associations between PA and BC risk by menopausal status and molecular subtype.Methods1389 histologically confirmed invasive BC cases and 1712 controls from the MCC-Spain study were included (age: 20 –85 years). Questionnaire information on PA at work, at home, and during leisure time, including recreational PA and sedentary time, and data on reproductive history, anthropometry, family history of BC, diet, and lifestyles were obtained through face...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionPremenopausal Asian women with breast cancer have unique disease characteristics and may benefit from treatment that differs somewhat from international guidelines. Given the great diversity of patients and clinical settings worldwide, the ABCCG advocates evidence-based yet flexible and individualized use of all potential options to improve breast cancer outcomes.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
AbstractPurposeGene expression profiling (GEP) test scores calculate risks of recurrence and likely benefit of adjuvant chemotherapy in ER-positive, HER2-negative, early-stage breast cancer. As health literacy and numeracy skills in the general population are poor, healthcare professionals (HCPs) require a wide repertoire of communication skills to explain clearly risk of recurrence scores (RSs) and uncertainty. We developed and evaluated an educational program for HCPs discussing GEP test results and adjuvant treatment.MethodsEight-hour workshops contained elements aimed at improving knowledge, communication skills and se...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionPreoperative CEA and CA15-3 levels showed varying prognostic ability according to breast cancer subtype. Preoperative CA15-3 and CEA elevation are significant prognostic factors for luminal breast cancer, but they were not significant factors for TNBC.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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