USPSTF calls for more BRCA1/2 genetic screening, testing
Broader recommendations on screening for BRCA1/2 genetic mutations published...Read more on AuntMinnie.comRelated Reading: Men need breast cancer screening too MRI finds breast cancer early in women with family history PET tracers help guide breast cancer therapies Breast cancer mutation increases interval cancer risk Screening breast MRI alone OK for high-risk women
In conclusion, we identified that EJ suppressed the growth of TNBC cells via targeting the STAT3 signaling pathway. These results strongly support that EJ is a promising therapeutic agent for TNBC.
Condition: Breast Cancer Intervention: Genetic: XIST gene deletion Sponsor: Assiut University Not yet recruiting
Conclusions: Collectively, TSGA10 functional expression alters under the hyper-/hypo-glycemia and hypoxia, which indicates its importance as a candidate bio-target for the cancer therapy. PMID: 31508330 [PubMed]
In conclusion, exposure to luminal neratinib resulted in a pronounced elevation in fluid secretion in the rat intestine. Increasing luminal calcium inhibits the neratinib‐associated fluid secretion in a dose‐dependent manner. These results suggest that CaSR activation may be a potent therapeutic target to reduce chemotherapy‐associated diarrhea.
The 2019 Lasker medical and research awards celebrate advances in scientists’ understanding of T and B cells, Herceptin antibodies for treating breast cancer, and vaccine coverage around the...
Publication date: Available online 9 September 2019Source: Redox BiologyAuthor(s): Carlos César Patiño-Morales, Ernesto Soto-Reyes, Elena Arechaga-Ocampo, Elizabeth Ortiz-Sánchez, Verónica Antonio-Véjar, José Pedraza-Chaverri, Alejandro García-CarrancáAbstractCurcumin is a natural phytochemical with potent anti-neoplastic properties including modulation of p53. Targeting p53 activity has been suggested as an important strategy in cancer therapy. The purpose of this study was to describe a mechanism by which curcumin restores p53 levels in human cancer cell lines.HeLa,...
It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited for this goal.
Publication date: November 2019Source: Journal of Functional Foods, Volume 62Author(s): Yu-Qin Zhao, Lun Zhang, Guo-Xu Zhao, Yin Chen, Kun-Lai Sun, Bin WangAbstractDoxorubicin (DOX) is a commonly used anthracycline in treatments of leukemia, lymphoma and breast cancer in humans and has been limited by its cardiotoxicity, which is manifested congestive heart failure in the worst condition. The present study showed that the marine carotenoid of fucoxanthin could exert cardioprotective effect against the DOX-induced injury in ICR mice. And then, the protective effects and mechanisms of fucoxanthin on DOX-induced injury of neo...
In this study, we explored the cytotoxic effect of recombinant human IL-2 in combination with Trastuzumab and Pertuzumab on the ERBB2 positive (SK-BR-3) and negative (MDA-MB-231) breast cancer cell lines. The cytotoxicity level of IL-2 activated NK cells (approximately 75%) were significantly higher than untreated cells (approximately 55%) in the presence of Trastuzumab and Pertuzumab against SK-BR-3 cells, while no difference was observed in the case of MDA-MB-231 cells (about 15%). PMID: 31493284 [PubMed - as supplied by publisher]
ConclusionResults from studies published to date indicate that among women receiving primary breast cancer therapy, home-based physical activity programs have positive effects on physical functioning and symptoms such as fatigue. Among women receiving adjuvant chemotherapy or radiation therapy, home-based physical activity programs are effective in reducing symptoms and improving physical functioning. Additional studies are needed to clarify the impact of home-based physical therapy interventions on other outcomes including quality-of-life, bone mineral density, cognitive functioning, and chemotherapy-induced peripheral neuropathy.