αEβ7 Expression Increases With the Extent of Cutaneous Involvement in Mycosis Fungoides

Conclusions: The findings presented here support the idea that the lymphocyte migratory mechanism observed in neoplasms is similar to that of inflammatory processes of the skin.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research

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Mycosis fungoides cutaneous-type T-cell lymphoma (MF-CTCL) is a rare non-Hodgkin lymphoma. In patients with early stage MF-CTCL, topical chlormethine (=mechlorethamine) 0.016% w/w gel (equivalent to 0.02% chlormethine HCl) was reported safe and effective, but usage may be limited due to the development of contact dermatitis. The primary endpoint of the current study was to determine if Triamcinolone significantly reduces the development of chlormethine-induced contact dermatitis using the newly formulated 0.016% w/w gel.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive Immunity and Autoimmunity Source Type: research
We report a 48-year-old female seamstress presenting with a 2-year history of dyshirotic dermatitis-like eruption on the hands and feet, which was treated as pompholyx with systemic and topical corticosteroids, methotrexate, cyclosporine, and cyclophosphamide therapy previously in a rheumatology clinic.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Authors: Nedelcu RI, Balaban M, Turcu G, Brinzea A, Ion DA, Antohe M, Hodorogea A, Calinescu A, Badarau AI, Popp CG, Cioplea M, Nichita L, Popescu S, Diaconu C, Bleotu C, Pirici D, Popescu R, Popescu CM, Zurac SA Abstract Methotrexate (MTX) is a folic acid analog with anti-proliferative (anti-neoplastic, cytotoxic), immunosuppressive and anti-inflammatory properties, which has been used in the treatment of various cutaneous disorders, such as psoriasis, keratoacanthoma, pityriasis rubra pilaris, atopic dermatitis, mycosis fungoides, bullous skin diseases, systemic sclerosis, morphea, lupus erythematosus, dermatomyo...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
We present a case of a 58-year-old man who presented with 5 years of cutaneous symptoms and several months of fevers and night sweats, ultimately diagnosed as MF. Owing to diffuse CD30 positivity, he was a candidate for brentuximab vedotin, an antibody-drug conjugate medication that selectively targets the CD30 antigen. This resulted in an excellent therapeutic response.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
We describe a 72-year-old man, who presented with a two-year history of an unusual eruption, which started on the abdomen, around the waistline, and gradually spread to involve his back, trunk, and buttocks. Clinically,...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
PMID: 31045233 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Erica S. Tarabadkar† and Michi M. Shinohara*† Division of Dermatology, University of Washington, Seattle, WA, United States Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Cioplea M, Caruntu C, Zurac S, Bastian A, Sticlaru L, Cioroianu A, Boda D, Jugulete G, Nichita L, Popp C Abstract Dendritic cells (DCs) are antigen-presenting cells with an important role in the innate and adaptive immune system. In skin lesions, cutaneous DCs (Langerhans cells, dermal DCs and plasmacytoid DCs) are involved in immune activation in inflammatory benign lesions, as well as in malignant lymphoid proliferations. Density and distribution of DCs in the dermal infiltrate can be helpful to differentiate benign, reactive infiltrate from malignant nature of the lymphoid population. We performed a ret...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In the early 1980s, 313-nm wavelength was reported to have potential efficacy for treating psoriasis [1,2]. A fluorescent lamp emitting selective ultraviolet B (UVB) light ranging from 311 to 313  nm was developed for narrowband UVB therapy and widely used to treat various skin diseases, such as psoriasis, vitiligo, atopic dermatitis, and mycosis fungoides [3–5]. Narrowband UVB lamps contain mercury, however, and thus have a large environmental burden. In the early 2000s, targeted photot herapy devices using a xenon-chloride excimer laser or lamp emitting 308 nm as a mercury-free light source were devel...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
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