Occurrence of acute myeloid leukemia in hydroxyurea-treated sickle cell disease patient.
Occurrence of acute myeloid leukemia in hydroxyurea-treated sickle cell disease patient.
Cancer Biol Ther. 2019 Aug 18;:1-9
Authors: Regan S, Yang X, Finnberg NK, El-Deiry WS, Pu JJ
Abstract
Hydroxyurea (HU) has been widely used in sickle cell disease. Its potential long-term risk for carcinogenesis or leukemogenic risk remains undefined. Here, we report a 26 y old African-American female with Sickle Cell Disease (SCD) who developed refractory/relapsed acute myeloid leukemia (AML) 6 months after 26 months of HU use. That patient's cytogenetics and molecular genetics analyses demonstrated a complex mutation profile with 5q deletion, trisomy 8, and P53 deletion (deletion of 17p13.1). P53 gene sequence studies revealed a multitude of somatic mutations that most suggest a treatment-related etiology. The above-mentioned data indicates that the patient may have developed acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) as a direct result of HU exposure.
PMID: 31423878 [PubMed - as supplied by publisher]
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Regan S, Yang X, Finnberg NK, El-Deiry WS, Pu JJ Tags: Cancer Biol Ther Source Type: research
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