PGE1-assisted treatment of microcirculation disturbance in complicated falciparum malaria.

This article reports the course of a complicated malaria in a 41-year-old male patient. After spending several months in Mali, the patient decompensated shortly after onset of the first symptoms. Under the signs of a multi-organ failure and with an initial parasitic load of 25%, the patient developed a microcirculation disturbance in the acra. In addition to sepsis-induced disseminated microthrombosis, high-dose catecholamine treatment contributes to the genesis of this disease with a high clinical probability. To improve the peripheral blood circulation, intravenous treatment with the synthetic prostaglandin E1 (PGE1) alprostadil with 20 μg (1-0-1) was carried out over a period of 21 days. Relevant circulatory depression as a side effect did not occur. The microcirculatory disturbances were no longer evident and the necrosis healed. Furthermore, the clearance course of the plasmodia was delayed under artemisinin-based combination therapy. Prolonged hemolysis required multiple transfusions. PMID: 31420706 [PubMed - as supplied by publisher]
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research

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Conclusions. Plasmodium falciparum malaria was characterized by depression of cellular and humoral immunity, the degree of which depended on the severity of the pathological process. PMID: 31308850 [PubMed]
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
Conclusions Toxoplasma gondii infection induces a strong innate and adaptive immune response. While the innate immunity is important for controlling the early stages of the infection (Yarovinsky, 2014), the adaptive immunity is critical for restricting the parasite replication during the later stages (Gazzinelli et al., 1992). Amongst the adaptive immune subsets, CD8 T cells are the primary effector cells while CD4 T cells play an essential helper role to maintain long-term immunity (Casciotti et al., 2002). Notwithstanding, a robust CD8 T cell immunity induced during acute phase of infection, does not result in the total...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
This study showed that although head lice are arrested around human scalp samples, they did not show differences between the human samples of different volunteers nor with the aging of the scalp sample (i.e., 60 h-old samples are as much attractive as 0 h-old samples) (Ortega Insaurralde et al., 2016). Thus, a piece of filter paper (1 cm × 1 cm) was rubbed during 30 s against the scalp of one 30-year-old female volunteer who had not bathed or used perfumed products in the 24 h previous to the extraction. Immediately after rubbing, the filter paper was located at one side of the circ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 007 When you think tropical medicine, malaria has to be near the top. It can be fairly complex and fortunately treatment has become a lot simpler. This post is designed to walk you through the basic principals with links to more in depth teaching if your niche is travel medicine, laboratory diagnostics or management of severe or cerebral malaria. If you stubbled on this post while drinking a cup of tea or sitting on the throne and want a fe...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine malaria Plasmodium plasmodium falciparum plasmodium knowles plasmodium malariae plasmodium ovale plasmodium vivax Source Type: blogs
N, Neto PJR Abstract Caused by Trypanosoma cruzi, Chagas disease is responsible for public health problems greater in magnitude than those attributed to malaria, schistosomiasis, or leishmaniasis. A factor in the socioeconomic development of poor countries, Chagas disease can cause death due to a high parasitic burden during its acute phase due and irreversible damage in organs such as the heart, esophagus, and colon during its chronic phase, even when the number of parasites is minimal. For treating Chagas disease, benznidazole (BNZ) remains the drug of choice and, in Latin America, the only drug on the market fo...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
ConclusionsAs we have noted endlessly, the US spends more per capita on health care than any other developed country.  US politicians used to make the claim that the country has the best health care system in the world, often to ward off any attempts at true health care reform.  However, US rankings on various measures - some of which may be disputed - of health care processes and outcomes have been decidedly mediocre.  (See for example the latest Commonwealth Fund studyhere.)The new study of hookworm prevalence was not based on a big, systematic, or geographically diverse sample.  However it is strikin...
Source: Health Care Renewal - Category: Health Management Tags: government health care foundations public health Source Type: blogs
It is almost a tradition for me to publish predictions for the coming year. I do not mean to disappoint you this year either, so here you find some thoughts about the top medical technologies of 2017. 2016 was a rich year for medical technology. Virtual Reality. Augmented Reality. Smart algorithms analysing wearable data. Amazing technologies arrived in our lives and on the market almost every day. And it will not stop in the coming year. The role of a futurist is certainly not making bold predictions about the future. No such big bet has taken humanity forward. Instead, our job is constantly analysing the trends shaping t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine 3d printing AI artificial intelligence diabetes GC1 genetics Healthcare Innovation nutrigenomics Personalized medicine robotics wearables Source Type: blogs
AbstractA clinicalHaemoproteus columbae infection in a two  months rock pigeon was diagnosed on the basis of outward signs and blood smear examination. The clinical signs suggestive of pigeon malaria were anorexia, depression, inability to fly, circling movements and episodes of torticollis. The characteristic halter shaped gametocytes were seen, in thin b lood smear, encircling the nucleus of erythrocytes. Buparvaquone therapy, two intramuscular injections at the rate of 5 mg/kg at 72 h interval, was successful. Supplementation of multivitamin helped in speedy recovery and clinical signs along with uncommon...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
How much do you know about DNA? National DNA Day is celebrated on 25 April, to recognize the anniversary of the successful completion of the Human Genome Project in 2003 and the discovery of DNA’s double helix in 1953. The goal of this special day is to offer students, teachers, and the public an opportunity to learn about the latest advances in genomic research, and how those advances might impact all of our lives. Take our quiz to see how much you know! Microbiome and the modern environment Journal of Physiological Anthropology published a series looking at the effects of the modern environment on the microbiome, a...
Source: BioMed Central Blog - Category: Journals (General) Authors: Tags: Biology Health Medicine blogs digest Source Type: blogs
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