Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda.

The objective of this study was to determine the prevalence of malaria/TB coinfection among bacteriologically confirmed adult TB patients at a national TB treatment centre in Uganda. Using a cross-sectional study design we enrolled 363 bacteriologically confirmed adult TB patients, and data on demographics and medical history was collected. Blood samples were tested for malaria blood smear, rapid malaria diagnostic test (RDT), complete blood count, haematological film analysis, HIV serology, and CD4+ and CD8+ cell counts. Malaria was defined as either a positive blood smear or RDT. The study participants were mostly male (61.4%), with a median age of 31 (interquartile range, IQR: 25-39) years, and 35.8% were HIV positive. The prevalence of malaria was 2.2% (8/363) on the overall and 5% (3/58) among participants with rifampicin resistance. A triple infection of HIV, malaria, and rifampicin resistant TB was observed in 3 participants. The prevalence of malaria among TB patients is low, and further evaluation of the epidemiological, clinical, and immunological interaction of the two diseases is warranted. PMID: 31428162 [PubMed]
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research

Related Links:

[Leadership] Chevron has revealed that it is spending over $5 million (about N1.9 billion) to support the federal government's fight against tuberculosis, malaria and HIV in the country since 2017.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent FindingsCombining mechanistic models and machine learning algorithms has led to improvements in the treatment ofShigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the i...
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research
This article focuses on the impact of the COVID-19 pandemic on child health in sub-Saharan Africa. We review the epidemiology of major pediatric diseases and, referencing modeling projections, discuss the short- and long-term impact of the pandemic on major disease control. We deliberate on potential complications of SARS-CoV-2 co-infections/co-morbidities and identify critical social and ethical issues. Furthermore, we highlight the paucity of COVID-19 data and clinical trials in this region and the lack of child participants in ongoing studies. Lastly, approaches and interventions to mitigate the pandemic's impact on chi...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Trauma contributes significantly to the burden of disease and mortality throughout the world, particularly in low- and middle-income countries (LMICs) [1]. Globally, injuries cause over five million deaths annually; this is 32% more than deaths due to HIV, tuberculosis and malaria combined [2]. Ninety percent of injury-related deaths occur in LMICs, where there are inadequate resources to provide the appropriate care to optimise patient outcomes [3].
Source: Injury - Category: Orthopaedics Authors: Source Type: research
Conclusion: Morocco was the first country in the Global Fund's Middle/East North Africa region to invest its entire Global Fund allocation in strengthening the health system. Many important lessons have been learned from this novel experience and these are presented for shared learning. This opportunity for learning is timely as countries begin preparations for the upcoming funding cycle. PMID: 32896891 [PubMed - in process]
Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
In Togo, the National Malaria Control Programme, in collaboration with the Global Fund to Fight AIDS, Tuberculosis and Malaria, has implemented a pilot study for malaria sentinel surveillance since 2017, which...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Abstract Severe acute malnutrition (SAM) is associated with a complex pattern of various clinical conditions. We investigated how risk factors cluster in children with SAM, the relationship between clusters of risk factors and mortality as well as length of stay in children with SAM. A prospective observational study design was used. Data were extracted from medical records of 601 infants and children aged 0-59 months admitted and treated for SAM in three Ghanaian referral hospital between June 2013-June 2018. Among the 601 medical records extracted, 99 died. Three clusters of medical features clearly emerged from...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research
In conclusion, I hope that you will buy this book and share it with your family and friends. It is meant to be a conversation piece. Instead of gathering dust on a bookshelf, it is designed to lie on a living room table (like so many architecture and interior design books), for visitors to see and discuss over a martini or glass of wine. I hope that it will alleviate some depression and anxiety, spark a fact ‐​filled discussion around the dining room table, and maybe even change some minds. Strangers things have happened. Cheers!
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
AbstractPurpose of ReviewIn this commentary, we summarize and put into perspective the recent information that highlights the associations between coronavirus disease and poverty. We also bring attention to another dimension that will most likely exacerbate the severity and long-term sequelae of COVID-19 in impoverished populations, that is, the comorbidities and the presence of tropical infections.Recent FindingsDuring this first half of 2020, the COVID-19 pandemic has emerged as a poverty-related neglected disease on at least two fronts. First, is its significant impact in low-income neighborhoods in the USA, the epicent...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
Authors: Vijayakumar S, Viswanathan S, Jain D Abstract Platelet indices have been used to diagnose and prognosticate infections such as tuberculosis, malaria, dengue, and septic shock. Platelet indices have previously not been used in the prediction of multiorgan dysfunction (MODS) in patients with scrub typhus. A three-year retrospective review of patient charts was performed. Patients with and without MODS were compared. Platelet indices and other clinical and laboratory variables were used in logistic regression analysis to determine significant predictors. A ROC curve was generated with the platelet indices to ...
Source: Interdisciplinary Perspectives on Infectious Diseases - Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research
More News: Allergy & Immunology | Epidemiology | Malaria | Papanicolaou (Pap) Smear | Study | Tropical Medicine | Tuberculosis | Uganda Health