Deaths: Betty Carnegie "Monty" Montgomery

On 9 August 2019,  Betty Carnegie “Monty” Montgomery, aged 82 years, of Glasgow. A former member of the Royal Pharmaceutical Society, Mrs Montgomery registered with the Society in 1960 and was designated Fellow in 1983. She was elected to the Royal Pharmaceutical Society of Great Britain’s Scottish Executive in 1975 and chaired the Scottish Executive from 1984 until 1986. 
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research

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CONCLUSION: There is a high prevalence of MRSA causing abscesses in the Hispanic population evaluated in an ED in Puerto Rico. Systemic antibiotic use for the treatment of skin abscesses after incision and drainage remains high despite published guidelines arguing against their widespread use. Clindamycin resistance in our patient population appears to be more frequent than previously reported. PMID: 33031694 [PubMed - as supplied by publisher]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
The difference in sequential organ failure assessment (SOFA) scores from the baseline to sepsis is a known predictor of sepsis-3 outcome, but the prognostic value of drug-resistant organisms for mortality is unexplained. We employed sepsis stewardship and herein report an observational study. Study subjects were patients admitted to the Departments of Surgery/Chest Surgery from 2011 through 2018 with a diagnosis of sepsis and a SOFA score of 2 or more. Our sepsis stewardship methods included antimicrobial and diagnostic stewardship and infection control. We determined the primary endpoint as in-hospital death and the secon...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Authors: Saxena D, Kaul G, Dasgupta A, Chopra S Abstract Acute bacterial skin and skin structure infections (ABSSSIs) are one of the most common types of infections due to methicillin-resistant Staphylococcus aureus (MRSA). The standard of care for ABSSSI includes glycopeptides such as vancomycin, teicoplanin, oxazolidinones and fluoroquinolones, which are potent broad-spectrum antibacterial agents. Unfortunately, due to indiscriminate utilization, resistance to these agents is rising and identification of novel agents is an urgent unmet medical need. In this context, levonadifloxacin (WCK-771) is a novel, hydrate ...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
Biofilms pose a relevant factor for wound healing impairment in chronic wounds. With 78% of all chronic wounds being affected by biofilms, research in this area is of high priority, especially since data for evidence-based selection of appropriate antimicrobials and antiseptics is scarce. Therefore, the objective of this study was to evaluate the anti-biofilm efficacy of commercially available hypochlorous wound irrigation solutions compared to established antimicrobials. Using an innovative complex in-vitro human plasma biofilm model (hpBIOM), quantitative reduction of Pseudomonas aeruginosa, Staphylococcus aureus, and Me...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: December 2020Source: Microbial Pathogenesis, Volume 149Author(s): Tayyab ur Rehman, Rizwan Aslam, Amjad Islam Aqib, Mashkoor Mohsin, Asad Manzoor, Muhammad Shoaib, Muhammad Aamir Naseer, Ali Hasan, Huma Sattar, Muhammad Fakhar-e-Alam Kulyar, Iqra Muzammil, Wangyuan Yao
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Abstract Quaternary ammonium compounds (QACs) comprise a large class of surfactants, consumer products, and disinfectants. The recently-isolated QAC natural product tricepyridinium bromide displays potent inhibitory activity against S. aureus but due to its unique structure, its mechanism of action remains unclear. A concise synthetic route to access tricepyridinium analogs was thus designed and four N-alkyl compounds were generated in addition to the natural product. Biological analysis of these compounds revealed that they display remarkable selectivity towards clinically-relevant Gram-positive bacteria exceedin...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
Future Microbiology,Volume 15, Issue 13, Page 1265-1276, September 2020.
Source: Future Microbiology - Category: Microbiology Authors: Source Type: research
Conclusions: Our results provide novel evidence that the product of P. intermedia exerts a pathogenic effect on MRSA pneumonia, in particular with a strain exhibiting strong proliferation in the lower airway tract. Moreover, our results indicate that P. intermedia affects MRSA toxin expression via quorum sensing in a strain-dependent fashion, which might be important for understanding the pathogenesis of severe MRSA pneumonia.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study characterized the epidemiological status, antibiotic resistance patterns, and current prevalent phenotypes of healthcare-associated MRSA. This knowledge can aid clinicians in improving the antimicrobial stewardship program by adapting appropriate guidelines for the proper use of MRSA antibacterial agents. PMID: 33012280 [PubMed - as supplied by publisher]
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
Conclusion A 5-day universal decolonization protocol before LVAD implantation was effective in reducing total infections as well as MRSA-specific infections.
Source: Dimensions of Critical Care Nursing - Category: Nursing Tags: Research DIMENSION Source Type: research
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