A case of vasculitic wheals

Urticarial vasculitis is a rare diagnosis defined by its distinct clinical and pathologic entities. The majority of cases are idiopathic; however, it has been linked to various etiologies including autoimmune, viral, paraneoplastic as well as pharmacotherapy. A 42-year-old Jamaican woman G1PO with sickle cell trait was admitted for persistent fevers and rigors for 2 weeks. This was associated with progressive burning, erythematous, raised plaques and patches involving the chest and trunk. While hospitalized she continued to spike fevers up to 103 °F despite being on broad spectrum antibiotics and acetaminophen.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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Publication date: January 2020Source: LWT, Volume 117Author(s): Songwen Tan, Chao Zhong, Timothy LangrishAbstractPre-gelation of whey protein isolates (WPI), a milk protein, has been performed before spray drying to decrease the solubility of WPI. The heat-induced pre-gelation at 80 °C aims to produce the gelled WPI for microencapsulation and sustained releases. The gelation time has been studied for a good spray drying, since the feed solutions with higher viscosities cannot be spray dried. WPI solutions cannot be gelled at lower pHs. SEM images show that the spray-dried WPI-acetaminophen particles have wrinkled sur...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Acetaminophen (APAP) is an analgesic–antipyretic drug and widely used in clinics. Its overdose may cause serious liver damage. Here, we examined the mechanistic role of c-Jun N-terminal kinase (JNK) signaling pathway in liver injury induced by different doses of APAP. Male mice were treated with APAP (150 and 175 mg·kg−1), and meanwhile JNK inhibitor SP600125 was used to interfere APAP-induced liver damage. The results showed that JNK signaling pathway was activated by APAP in a dose-dependent manner. C-Jun N-terminal kinase inhibitor decreased JNK and c-Jun activation significantly (P
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We would like to thank James R. Smith and colleagues1 for validating our ANCA renal risk score and confirming our results.2 The unmet need in antineutrophil cytoplasmic antibody –associated vasculitis is a robust risk stratification model to reduce recurrent disease damage and mortality. The key goal is to stratify treatment according to clinico-pathologic risk factors and a reliable biomarker panel predicting vasculitis behavior. This would improve renal and patient surv ival. Therefore, we encourage further validations to refine our score and improve its prognostic value.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
[Vanguard] The Doctor SickleCell Centre For Sickle Cell Disease in association with Olusegun Obasanjo Foundation has concluded plans to hold intervention programs for sickle cell disorder in Africa.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Point-of-care testing is useful for newborn screening for sickle cell disease (SCD) in low-income settings, according to results from an observational study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Pediatrics News Source Type: news
Updated Date: Thu, 19 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Thu, 19 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Thu, 19 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Thu, 19 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Thu, 19 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
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