A novel case of TIF1-gamma autoantibody positive dermatomyositis associated with a nonfunctional pancreatic neuroendocrine tumor

Introduction: Dermatomyositis (DM) is an idiopathic inflammatory myopathy that presents with proximal muscle weakness accompanied by a characteristic rash. The relationship between DM and malignancy is well established in the literature, with malignancy identified in approximately 25% of cases of DM. The most commonly associated malignancies are ovarian, lung, gastric, pancreatic and bladder adenocarcinomas. The presence of transcriptional intermediary factor 1- γ (TIF1-γ) autoantibodies in patients with DM is associated with higher rates of malignancy than those without the autoantibody.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research