Activation of nociceptive fibers following skin injury triggers antiviral host defense immunity

Multiple innate immune signaling pathways become activated upon skin injury in order to reestablish the antimicrobial barrier and prevent infection. Damage to the skin barrier often elicits pain and/or itch, and leads to activation of the nervous system which communicates intimately with the immune system in a variety of skin inflammatory conditions (Kashem& Kaplan, 2016; Riol-Blanco et al. 2014, Chiu et al. 2013, Ding et al. 2016). Given that sensory dorsal root ganglion neurons express toll-like receptors that sense viral nucleic acids (Chiu et al.

Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research