Assessment of skin microbiome diversity and skin health in dry skin and dry, itchy skin: A bilateral, controlled clinical trial using oat-containing lotions and wash

Healthy skin is colonized with a diverse population of microorganisms and typically harbors higher microbial diversity than atopic skin. Despite this understanding, there is little known about the microbiome of dry skin as compared with normal skin and how microbial populations are affected by use of topical products. A single-center, evaluator-blinded, randomized, split-leg clinical trial was conducted to evaluate the efficacy of two treatment regimens on the lower legs of 76 female subjects, ages 18-55, with clinically graded dry or dry/itchy skin.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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Itchy skin, or pruritus, is common and can affect any part of the body. Many factors can cause itchy legs, including skin conditions, diabetes, or allergic reactions. Learn about causes and treatments here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Dermatology Source Type: news
Updated Date: Thu, 19 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Chronic pruritus causes major morbidity in epidermolysis bullosa (EB). The substance P-neurokinin 1 receptor (SP-NK1) pathway is a promising target for treating EB-related pruritus.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
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Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Updated Date: Mon, 16 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Thu, 12 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
When I worked at Greenpeace for five years before I attended medical school, a popular slogan was, “think globally, act locally.” As I write this blog about climate change and hay fever, I wonder if wiping off my computer that I’ve just sneezed all over due to my seasonal allergies counts as abiding by this aphorism? (Can you clean a computer screen with a tissue?) Come to think of it, my allergies do seem to be worse in recent years. So do those of my patients. It seems as if I’m prescribing nasal steroids and antihistamines, recommending over-the-counter eye drops, and discussing ways to avoid all...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Environmental health Source Type: blogs
Updated Date: Tue, 10 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Patients with liver diseases often suffer from chronic itch, yet the pruritogen(s) and receptor(s) remain largely elusive. Here, we identify bile acids as natural ligands for MRGPRX4. MRGPRX4 is expressed in human dorsal root ganglion (hDRG) neurons and co-expresses with itch receptor HRH1. Bile acids elicited Ca2+ responses in cultured hDRG neurons, and bile acids or a MRGPRX4 specific agonist induced itch in human subjects. However, a specific agonist for another bile acid receptor TGR5 failed to induce itch in human subjects and we find that human TGR5 is not expressed in hDRG neurons. Finally, we show positive correlat...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
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