Cannabinoids for the treatment of refractory chronic pruritus

Background: Chronic pruritus is a distressing medical condition that is associated with significantly decreased quality of life and multiple comorbidities. There are currently no FDA approved therapies specifically for the treatment of chronic itch, and off-label treatment is often times used for patients with severe itch. Recent literature suggests that the antiinflammatory and analgesic properties of cannabis make cannabinoid therapy an option for dermatologic conditions, especially in the treatment of chronic pruritus.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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Updated Date: Thu, 12 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
When I worked at Greenpeace for five years before I attended medical school, a popular slogan was, “think globally, act locally.” As I write this blog about climate change and hay fever, I wonder if wiping off my computer that I’ve just sneezed all over due to my seasonal allergies counts as abiding by this aphorism? (Can you clean a computer screen with a tissue?) Come to think of it, my allergies do seem to be worse in recent years. So do those of my patients. It seems as if I’m prescribing nasal steroids and antihistamines, recommending over-the-counter eye drops, and discussing ways to avoid all...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Environmental health Source Type: blogs
Updated Date: Tue, 10 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Patients with liver diseases often suffer from chronic itch, yet the pruritogen(s) and receptor(s) remain largely elusive. Here, we identify bile acids as natural ligands for MRGPRX4. MRGPRX4 is expressed in human dorsal root ganglion (hDRG) neurons and co-expresses with itch receptor HRH1. Bile acids elicited Ca2+ responses in cultured hDRG neurons, and bile acids or a MRGPRX4 specific agonist induced itch in human subjects. However, a specific agonist for another bile acid receptor TGR5 failed to induce itch in human subjects and we find that human TGR5 is not expressed in hDRG neurons. Finally, we show positive correlat...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
High-dose chemotherapy (HDT) followed by autologous hematopoietic stem cell transplantation (ASCT) is widely used in patients with malignant lymphomas. In Europe over 8,000 ASCTs for lymphoma were performed out of a total of 40,000 transplants according to the European Bone Marrow Transplant (EBMT) activity survey in 2017. ASCT is considered the standard treatment for eligible patients failing to achieve remission after first line chemotherapy or patients with relapsed or refractory lymphomas, including classical Hodkin's lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma, as well as con...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Acupuncture might be effective at reducing itch intensity and may be more effective than conventional medicine at reducing EASI and improving the global symptoms of AE. PROTOCOL REGISTRATION: PROSPERO CRD42018096261. PMID: 31495184 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - Category: Complementary Medicine Authors: Tags: Acupunct Med Source Type: research
Gary, founder of Wheat-Free Market, shared his 8-year update living the Wheat Belly lifestyle. “The passing of Labor Day weekend marked 8 years since I began my grain-free journey to weight loss and better health. In these years I haven’t had a single bite of bread, pasta, pizza, or cake, unless they were made with the ingredients we have come to love as alternatives to cereal grains. The profound changes in me resulting from this simple dietary change are what drove me to create Wheat-Free Market Foods, so I could offer others not only food products but recipes to support this lifestyle. “I cringe when I...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open Inflammation Weight Loss wheat belly Source Type: blogs
ing Because of exposure to a number of potential health hazards within the work environment, hairstylists experience occupational diseases that include occupational asthma, skin conditions and musculoskeletal diseases. The paucity of studies assessing occupational safety and hygiene management among Afro-Caribbean hair salon operators in the UK promoted the study. QualtricsTM was used to assess the participants’ perception of exposure to hair products and their personal safety and hygiene knowledge, attitudes, awareness, and risk perceptions at work. In five salons, indoor air quality was monitored over one w...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Ishwor Gurung, Yan Gao, Kai Han, Xue-Biao PengIndian Journal of Dermatology 2019 64(5):414-416 Langerhans cell histiocytosis (LCH) is a proliferative disease commonly seen in the pediatric population but rarely encountered in the adult population. The exact etiology remains unclear. It has various clinical features and is very likely to be misdiagnosed. Histopathology and immunohistochemistry are very important for the diagnosis of LCH. Treatment protocols remain controversial. Herein, we report a rare adult onset LCH, which is confined to the skin. A 50-year-old Chinese man presented with a nodule with itchy rashes on th...
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Updated Date: Wed, 04 Sep 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
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