Comparison of mortality and complications in adult versus pediatric staphylococcal scalded skin syndrome patients

Staphylococcal scalded skin syndrome (SSSS) is a skin blistering condition caused by the release of exotoxins by Staphylococcus aureus. Greater mortality and complications have been associated with adult SSSS as compared with pediatric SSSS. 827 patients of patients diagnosed with SSSS were investigated from 20032012 in the National Inpatient Sample (NIS). Adult patients ( ≥18 years) consisted of 28% of the patient population. Adult SSSS patients had significantly greater rates of Agency for Healthcare Research and Quality (AHRQ) standardized comorbidities including: deficiency anemia (P
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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Hereditary hemorrhagic telangiectasia (HHT) is a syndrome with easily recognizable mucocutaneous arteriovenous malformations (AVMs) and covert visceral AVMs. Upon diagnosis of HHT, screening is recommended for pulmonary, cerebral, gastrointestinal, and hepatic AVMs due to classically associated complications such as hemorrhage, cerebral abscess, high output heart failure, and iron deficiency anemia. Recently, extracerebral infection was found to be a common but under reported occurrence among patients with HHT, affecting approximately 9% of patients.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Conclusion In conclusion, this study wants to stress the importance of early diagnosis. As in the majority of primary immunodeficiency diseases, the prognosis of LAD3 is extremely dependent on early age diagnosis, with timely management of bacterial infections and consideration for HSCT. In addition, this autosomal recessive disorder has high incidence in areas with high rate of consanguineous marriages. Therefore, broadening the spectrum of known mutations underlying the phenotype of such a life-threatening disease can help offering and performing better genetic counseling and prenatal diagnosis. Ethics Statement This ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, the StCas9 derived from Streptococcus thermophilus together with the Drosha-mediated sgRNA-shRNA structure were combined to boost the G to A base editing on the IGF2 SNP site, which we called “SNP editing.” The codon-humanized StCas9 as we previously reported was firstly compared with the prevalently used SpCas9 derived from Streptococcus pyogenes using our idiomatic surrogate report assay, and the StCas9 demonstrated a comparable targeting activity. On the other hand, by combining shRNA with sgRNA, simultaneous gene silencing and genome targeting can be achieved. Thus, the novel IGF2.sgRNA-LIG4....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Erica S. Tarabadkar† and Michi M. Shinohara*† Division of Dermatology, University of Washington, Seattle, WA, United States Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In conclusion 82% of children did not adhere to penicillin. We have not demonstrated any benefit in adhering to prophylactic penicillin. Adherence is poor and alternative approaches of standby antibiotics should be considered. We suggest focusing on vaccination as a preventative strategy is of more benefit. Martin OO, Moquist KL, Hennessy,JM, Nelson SC. Invasive pneumococcal disease in children with sickle cell disease in the pneumococcal conjugate vaccine era. Pediatr Blood Cancer. 2018;65:e26713. https://doi.org/10.1002/pbc.26713Oligbu G, Collins S , Streetly A, Dick, M, Ladhany, S. Risk of invasive pneumococcal disease ...
Source: Blood - Category: Hematology Authors: Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical Source Type: research
Aim of this study is to evaluate clinical, radiological, microbiological and genetic properties of CF patients who refered for sweat test due to IRT positivity and diagnosed as CF.Of the 945 IRT/IRT positivity in 2015-2018, 30 patients (p)were diagnosed CF. The mean diagnostic age 1.5 m(1-3). At the time of diagnosis, malnutrition was present in 15. In 27 patients vitA, in 15 vitE and in 14 vitD deficiency detected. Anemia was present in 8(27%). Pseudo-Bartter's syndrome(PBS) was detected in 5. Antibiotic treatment was started in 5 infants because of respiratory infections. Salt, vitamins, and chest physiotherapy started f...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric bronchology Source Type: research
Conclusions Although it is difficult to determine the efficacy of TLV by itself, patients who received TLV for a longer duration than other antibiotics before EOTT were more likely to be cured as opposed to having an incomplete response compared with patients who received TLV as a smaller proportion of their total antibiotic days. A favorable outcome was achieved for many patients receiving the antimicrobial regimen that included TLV for the treatment of methicillin-resistant S. aureus bacteremia.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Original Articles Source Type: research
Publication date: Available online 10 March 2018 Source:Journal of Trace Elements in Medicine and Biology Author(s): Manfred Nairz, Stefanie Dichtl, Andrea Schroll, David Haschka, Piotr Tymoszuk, Igor Theurl, Günter Weiss The acute-phase response is triggered by the presence of infectious agents and danger signals which indicate hazards for the integrity of the mammalian body. One central feature of this response is the sequestration of iron into storage compartments including macrophages. This limits the availability of this essential nutrient for circulating pathogens, a host defence strategy known as ‘nutrit...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Conclusion: Septicaemia in SCD confirmed children in the three hospitals are caused by a combination of 11 genera of bacteria. Resistance to commonly used antibiotics are on increase, but treatment with ciprofloxacin is still promising.
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
Conclusion: Septicaemia in SCD confirmed children in the three hospitals are caused by a combination of 11 genera of bacteria. Resistance to commonly used antibiotics are on increase, but treatment with ciprofloxacin is still promising.
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
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