Possible role of progranulin in Beh çet disease

Beh çet disease (BD), is a multisystemic, chronic vasculitis. Critical pathways in the yet unkown pathogenesis are TNF –alfa associated. Proinflammatory cytokines such as IL-8 and TNF- alfa are elevated with active disease. Neutrophils are a key player. PRGN is an endogeneous antagonist of TNF-alfa, and acts by competitively binding to TNFR. PRGN exerts potent anti-inflammatory effect. However, when degradaded by neutrophil proteases, an increase of IL-8 is seen, aggravating the neutrophilic inflamation.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research