Topical application of ASN008, a permanently charged sodium channel blocker, shows robust efficacy, a rapid onset and long duration of action in a mouse model of pruritus

Background: Pruritus, or itch, is associated with a wide variety of conditions, including skin and medical disorders, allergies and infections, and exposure to some medications. In many of these conditions, such as atopic dermatitis, the intense pruritus and associated scratching can result in exacerbation of the disease and a reduced quality of life. The itching sensation is transmitted through afferent C-fibers. Sodium channels play a key role in the transmission process. Indeed, topical local anesthetics, which block sodium channels and are used to treat itch, generally have a short duration of action, and importantly, are not selective for itch-sensing neurons.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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Chronic inflammatory skin diseases, such as atopic dermatitis, result from an overactive immune response in combination with epidermal barrier defects. The subsequent intrusion of allergens or pathogens stimulates keratinocytes to produce antimicrobial peptides, cytokines, and chemokines to restore epidermal homeostasis. One of these cytokines is thymic stromal lymphopoietin (TSLP), which plays a crucial role in TH2 immune responses by triggering dendritic cell activation and CD4+ T-cell differentiation.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting 15% to 20% of the general population in developed countries.1 It is characterized by recurrent eczematous legions and intense itch. Because the itch sensation induces scratching behavior, which exacerbates the skin inflammation and disturbs the quality of life of affected individuals, chronic itch is a challenging clinical problem in the treatment of AD.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
This study assessed the prevalence and detailed clinical features of CI among 153 elderly patients hospitalized in the geriatric ward, including associations with comorbidities and pharmacotherapy. CI affected 35.3% of subjects, most commonly due to cutaneous conditions, mixed aetiology and neurological disorders (53.7%, 25.9% and 11.1% of pruritic subjects, respectively). The mean itch intensity assessed with the 4-Item Itch Questionnaire (4IIQ) was 6.6 ± 2.8 points. Viral hepatitis (p = 0.02), higher serum creatinine concentration (p = 0.02) and coexistent purpuric lesions...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
Recent publications in The Annals of Allergy, Asthma and Immunology have documented the pain and suffering associated with cutaneous allergy.1,2 In the current issue of The Annals, Jonathan Silverberg reviews a number of comorbid health problems associated with atopic dermatitis (AD). Of greatest interest to allergists, AD predisposes to a higher risk of food allergy, eosinophilic esophagitis, and respiratory allergy.3 The systemic effects of AD are also manifested by a higher risk for infectious and cardiovascular risk.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
If you’re the type who dons new duds without washing them first, there’s a chance you may pay a price for it a few days later. A red, itchy, painful price. Allergic contact dermatitis is an immune system-related reaction to an allergen that has come into contact with your skin. It causes a delayed reaction: a rash that appears a few days after exposure, and then can last for weeks. “When we see allergic contact dermatitis from clothing, it’s usually from disperse dyes,” says Dr. Susan Nedorost, a professor of dermatology at Case Western Reserve University and director of the dermatitis program...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized chemicals Environmental Health Lifestyle Source Type: news
AbstractPurpose of the reviewThere are numerous causes of chronic pruritus (itch) which is associated with a variety of inflammatory skin diseases, including many primarily extracutaneous disorders. This review provides an overview of typical skin and systemic diseases involving pruritus. We focus on relevant molecular mechanisms of pruritus and the current therapeutic strategies.Recent findingsIL-31, released by eosinophil granulocytes, may play an important role in the neuromodulation of pruritus. Consequently, the anti-IL-31 antibody nemolizumab shows promising results in clinical trials. The novel IL-4 receptor antagon...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
Discussion Atopic dermatitis (AD) has a prevalence of 3-5% in the overall U.S. population but is increasing with an estimated 10-15% lifetime risk in childhood. It is even more common in children of color with a prevalence in African-American/black children of 17% and Hispanic children of 14%. Health care utilization data also appears to support more severe disease in children of color also. Atopic dermatitis or eczema is a common dermatological skin problem which characteristically is a pruritic, papular eruption with erythema. Like most papulosquamous eruptions it often occurs in intertrigenous areas in people with alle...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
ConclusionPain is a distinct symptom in AD, with heterogeneous frequency, characteristics, intensity and QOL impact. Pain was related to scratching, fissures, and/or inflamed red skin, and least from burning from topical medications. Skin pain should be assessed in AD patients and monitoring treatment response.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Eczema, atopic dermatitis, urticaria, and other inflammatory allergic cutaneous reactions cause itch. Itch often makes the patients scratch their skin, and persistent scratching can aggravate dermal conditions. Itch can even cause emotional disturbance and sleep loss. The management of itch is therefore a key component of the clinical treatment of patients with allergies.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
CONCLUSION: We present the case of allergic contact dermatitis (ACD) due to hypersensitivity to fentanyl with good tolerance to buprenorphine. Positive PT in this patient suggests a type IV hypersensitivity mechanism. Allergic reactions to opioids are frequently immediate, but delayed reactions could appear, especially when the drug is administered topically. PMID: 31131754 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
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