Acquired icthyosis underlying anaplastic T-cell lymphoma

Paraneoplastic icthyosis (PI) is an acquired icthyosis presenting as cutaneous xerosis and scaling of different severities associated with an underlying systemic disease that may be neoplastic or nonneoplastic in origin. A 59-year-old female with a history of diabetes and hypertension, presented to our dermatology department with a 1-month history of disseminated scaling, accompanied by pruritus, xerosis, asthenia, and nonintentional weight-loss of approximately 5 kg. Further physical examination revealed erythematous plaques in the sub-mammarian, axillary and inguinal folds consistent with intertrigo.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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In this study we assessed the diagnostic usefulness of transorbital sonography in IIH with a special focus on color Doppler imaging of the central retinal artery. IIH patients presented papilledema and enlarged ONSD. ONSD accurately predicted an increased intracranial pressure in IIH (cut-off: 5.8 mm, 81% sensitivity, 80% specificity). 24 h following therapeutic lumbar puncture ONSD diminished significantly, whereas papilledema was not changed. PSV (peak systolic velocity) and Vmean (mean flow velocity) of the central retinal artery were increased in IIH patients compared to controls. PSV accurately predicted an increa...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionsComparisons of CABG characteristics and outcomes were conducted between the STS National Database and JCVSD to illustrate the value of international collaboration off adult cardiac surgery databases.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Yang X Abstract Diabetic nephropathy (DN) is a serious complication of diabetes mellitus whose expand process is linked with the fibrosis, renal hypertrophy and inflammation. The current study was to formulate and optimize the nano-formulation of crocetin (CT-PLGA-NPs) against Streptozotocin-induced renal nephropathy in rats. Double emulsion evaporation technique was used for the preparation of CT-PLGA-NPs. CT-PLGA-NPs were scrutinized for polydispersity index, size, gastric stability, entrapment, drug-loading capacity and in-vitro drug release and in vivo preclinical study. Single intraperitoneal injectio...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Findings based on survey of university - affiliated students, staff with either type 1 or type 2 diabetes
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Endocrinology, Family Medicine, Internal Medicine, Nursing, Pediatrics, Psychiatry, Journal, Source Type: news
Authors: Petrakis I, Kontogiorgis C, Nena E, Athanasakis K, Gougoula V, Kotsianidis I, Constantinidis TC Abstract Introduction: Real-world effectiveness of hemato-oncology pharmaceuticals may not necessarily mimic clinical trial efficacy results, mainly due to demographic and clinical practice variability. The aim of this review was to systematically assess the availability of real-world evidence (RWE) and the transferability of clinical trial (CT) efficacy results to real life, for novel agents recently approved to manage lymphomas, leukemias and multiple myeloma. This is the largest cross-indication review compar...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Iyer KS, Dayal S Abstract Platelets are small, anucleated effector cells that play an important role in linking the hemostatic and inflammatory processes in the body. Platelet function is known to be altered under various inflammatory conditions including aging. A gain in platelet function during aging can increase the risk of thrombotic events, such as stroke and acute myocardial infarction. Anti-platelet therapy is designed to reduce risk of serious cerebrovascular and cardiovascular events, but the adverse consequences of therapy, such as risk for bleeding increases with aging as well. Age-associated co...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
CONCLUSION: Gingival recession is a common finding in the Colombian population. Factors associated with recession presence were the same as for periodontitis. Less frequent toothbrushing was associated with deep buccal recession. PMID: 31522165 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
Authors: Johnston MP, Patel J, Byrne CD Abstract Introduction The pandemic of obesity over the last two decades has triggered a rise in prevalence of non-alcoholic fatty liver disease (NAFLD). NAFLD is associated with liver-related- and cardiovascular complications. Despite this, the first licensed drug for NAFLD is yet to be approved. Given the scale of the problem and unmet needs, there is a myriad of agents in the development pipeline. Areas covered We discuss promising agents in early phase clinical trials and categorize these agents based on their action on steatosis, steatohepatitis and fibrosis. Furthermore,...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
ConclusionsMore frequent and regular primary care provider encounters are associated with an increased likelihood of non-insulin diabetes medication adherence. These findings contribute to data needed to establish evidence-based guidelines for primary care provider encounter cadence for those newly diagnosed with type 2 diabetes mellitus.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionGroup B streptococcal infection might become invasive in immunocompromised patients, so careful follow-up for those patients is important.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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