Glucagonoma: When to think of this diagnosis?

Introduction: Necrolytic migratory erythema (NME) may correspond to a paraneoplastic syndrome. It usually occurs in patients with glucagonoma, an alpha cell pancreatic tumor. When associated with weight loss, angular stomatitis, glossitis, diabetes mellitus, anemia and neuropsychiatric disorders defines the glucagonoma syndrome. NME lesions present as erythematous maculopapules with blisters and ulceration, occurring mostly on perineum, lower abdomen, extremities and face.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research