Herpes vegetans: Atypical perineal HSV infection in an immunocompromised patient

A 48-year-old woman with a history of AIDS and stage IV Hodgkin lymphoma status post chemotherapy and stem cell transplant presented with 8 months of painful perineal erosions and exophytic plaques. Her medical history was significant for acyclovir-resistant herpes simplex virus (HSV) and multiple opportunistic infections. Examination revealed diffuse discontinuous eroded plaques in the perineum, and scattered skin-colored and hyperpigmented exophytic plaques with raised borders and central craters overlying the sacrum, gluteal cleft, and perineum.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research