Ozenoxacin, a novel nonfluorinated quinolone for impetigo treatment: Its activity in resistant isolates involved in superficial skin infections

Background: Ozenoxacin (OZN), a novel nonfluorinated quinolone for the topical treatment of impetigo has shown to be effective against MRSA isolates.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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Source: OnMedica Latest News - Category: UK Health Source Type: news
Conclusions: Resistance patterns in a wide range of pathogens against oral or topical antibiotics and antiseptics used for the treatment of dermatological conditions, such as impetigo have been observed. When making treatment decisions for impetigo MRSA and other antimicrobial resistance has to be taken into account. Ozenoxacin 1% cream offers a potent bactericidal activity and has demonstrated clinical efficacy and safety. Combined with its favorable features, such as a low dosing frequency and a 5 days treatment regimen, ozenoxacin 1% cream is an important option for the treatment of impetigo for pediatric and adult popu...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
François Chassagne1†, Xinyi Huang1†, James T. Lyles1 and Cassandra L. Quave1,2* 1Center for the Study of Human Health, Emory University, Atlanta, GA, United States 2Department of Dermatology, Emory University, Atlanta, GA, United States In the search for new therapeutic solutions to address an increasing number of multidrug-resistant bacterial pathogens, secondary metabolites from plants have proven to be a rich source of antimicrobial compounds. Ginkgo biloba, a tree native to China, has been spread around the world as an ornamental tree. Its seeds have been used as snacks and medical mater...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSION: Despite the new emerging technologies and delivery systems, efforts are still needed in the right direction to combat this global challenge. PMID: 29807522 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Infective Drug Discovery - Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Authors: Marchese A, Schito GC, Debbia EA Abstract Staphylococcus aureus is a common cause of soft tissue infection, e.g. impetigo, cellulitis, or wound infection, and causes osteomyelitis, arthritis, bacteremia with metastatic infection, and scalded skin and toxic shock syndromes. Coagulase-negative staphylococci have become increasingly important causes of nosocomial bacteremia associated with invasive monitoring, intravascular catheters and prosthetic heart valves or joints. Most staphylococci produce blactamase and are resistant to penicillin. An increasing proportion of S. aureus have intrinsic resistance to m...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
ConclusionsThis original prospective multicentre study highlights stark differences in European MRSA epidemiology compared with the USA, and that the USA300 CA-MRSA clone is not predominant among community-infected patients in Europe.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research
Conclusions: BCs are not useful in the management of immunocompetent patients admitted to the hospital with uncomplicated SSTIs. The prevalence of CA-MRSA is low in our area, but continuing careful surveillance is needed.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Melting graft syndrome is a well established condition characterised by progressive epithelial loss from a previously well-taken skin graft, healed burn or donor site. Also known as ghosting graft syndrome or burn wound impetigo, the condition has largely been attributed to the effects of Staphylococcus aureus and its more virulent relation MRSA on newly epithelialising wounds. The resultant effect of this pathological burden is the appearance of patchy epithelial loss and a ‘moth-eaten’ graft.
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Tags: Letter to the Editor Source Type: research
Discussion Staphylococcus aureus is a gram-positive, catalase-positive coccal bacterium that is found on the skin and respiratory tract. It is the most common cause of skin and soft tissue abscesses. Staphylococcus can also cause enteritis, pneumonia, and toxic shock syndrome. In addition to abscesses, Staphylococcus can cause pustulosis, cellulitis, necrotizing fascitis and other exfoliative skin disease such as bullous impetigo. Staphylococcus is well-known to colonize the human skin, nail and nares. It is spread by physical contact and aerosolization. Skin breaches allow Staphylococcus to enter the body and to dissemin...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Abstract Skin infections are a common problem among athletes at all levels of competition; among wrestlers, 8.5% of all adverse events are caused by skin infections. Wrestlers are at risk because of the constant skin-to-skin contact required during practice and competition. The most common infections transmitted among high school wrestlers include fungal infections (e.g., ringworm), the viral infection herpes gladiatorum caused by herpes simplex virus-1 (HSV-1), and bacterial infections (e.g., impetigo) caused by Staphylococcus or Streptococcus species, including methicillin-resistant Staphylococcal aureus (MRSA)....
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
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