LB1053 Dysregulation of antioxidant enzyme PRDX5 in alopecia areata

We previously published a genome-wide association study (GWAS) and meta-analysis to search for common alleles that contribute to risk of AA, and identified several genomic regions harboring potential susceptibility genes. One candidate susceptibility gene expressed in the hair follicle (HF) in AA is peroxiredoxin 5 (PRDX5) (p= of 8.7*10-14), which is also a GWAS gene in Crohn ’s disease, sarcoidosis, and psoriasis. PRDX5 is a member of the family of antioxidant enzymes that are crucial for regulating oxidative stress.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research

Related Links:

Authors: Grilo F, Novara ME, D'Oca MC, Rubino S, Lo Bianco R, Di Stefano V Abstract Studying the sensory profile and chemical composition of monovarietal extra-virgin olive oils (EVOOs) is important to define and manage their quality and uniqueness. Chemical and sensory traits of olive oils from 14 minor Sicilian olive genotypes in comparison with oils from six major Sicilian and three international cultivars were analysed. Oils were extracted in 2015 from fruit of the 23 genotypes grown in an experimental orchard at a planting density of 1140 trees ha-1. Fatty acid composition, phenol composition, carotenoid conte...
Source: International Journal of Food Sciences and Nutrition - Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research
CONCLUSION: The selective oxidation of the methionine residue could be induced by the H2O2 produced in the reaction between gentisic acid and free radicals of water, during the protection of the radiolabelled peptide from the attack of these harmful species. Therefore, the addition of methionine becomes necessary to effectively decrease this selective oxidation in the methionine-containing peptide. PMID: 31526356 [PubMed - as supplied by publisher]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research
ConclusionThe widespread availability and recommendation of synthetic compounds for addressing human health have several side effects besides higher costs. Hence, examining natural bioactive compounds is imperative. This review investigates and presents the pertinent information on cardamom and its traditional uses, as well as potential pharmacological properties of CEO and extracts. Additional research studies are needed to understand the mechanism of action of bioactive constituents.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: November 2019Source: Biomedicine &Pharmacotherapy, Volume 119Author(s): Mohammed Sani Jaafaru, Norshariza Nordin, Rozita Rosli, Khozirah Shaari, Hauwa’u Yakubu Bako, Noramaliza Mohd Noor, Ahmad Faizal Abdull RazisAbstractThe antioxidant and neuroprotective activity of Glucomoringin isothiocyanate (GMG-ITC) have been reported in in vivo and in vitro models of neurodegenerative diseases. However, its neuroprotective role via mitochondrial-dependent pathway in a noxious environment remains unknown. The main objective of the present study was to unveil the mitochondrial apoptotic genes’ profil...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Af Björkesten CG, Jussila A, Kemppainen H, Hallinen T, Soini E, Mankinen P, Valgarðsson S, Veckman V, Nissinen R, Naessens D, Molander P Abstract Background and Aims: A retrospective non-interventional, multi-centre patient chart review study was conducted to investigate the association of faecal calprotectin (FC) 1 year (±2 months) after biological therapy initiation with composite event-free survival (CEFS) consisting of surgical procedures, corticosteroid initiation, treatment failure or dose increase in patients with Crohn's disease (CD). In addition, the correlations of F...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusions: This study identified a number of key genes and pathways involved in CD and potential drugs to combat it, which might offer insights into CD pathogenesis and provide a clue to potential treatments. PMID: 31526198 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
This study aimed to figure out the optimum fermentation temperature by analyzing the major chemical constituents of black tea and its antioxidant activities, inhibitory activities against α-amylase, α-glucosidase and glucose uptake. Sensory evaluation revealed 28°C-fermented black tea showed best sensory quality with highest scores for aroma (6.5) and taste (29.8). With increasing fermentation temperature, polyphenols, polysaccharides, (−)-epigallocatechin, (+)-catechin, theaflavins and thearubigins decreased significantly, while amino acids, soluble sugars and volatiles increased when temperature inc...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
This study aims to investigate the protective effects of morin hydrate (MH) against acute liver injury induced by carbon tetrachloride (CCl4) in mice and to elucidate the possible molecular mechanism of action. Mice were pretreated with MH (50 mg/kg body weight) or vehicle by oral gavage once daily for 5 days, followed by intraperitoneal injection of a single dose of CCl4 (1 ml/kg in olive oil). Mice were sacrificed 24 h later; the blood and liver samples were harvested for analysis. We also used the model of lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in vitro and examined the effects of MH and its mechanism ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we aim to investigate the potential role and effect of nuclear factor erythroid-2–related factor-2 (Nrf2) activation on diabetic wound healing. In vitro experiments in rat macrophages showed that hyperglycemia treatment suppresses Nrf2 activation, resulting in oxidative stress with decreased expression of antioxidant genes, including NAD(P)H:quinone oxidoreductase 1 and heme oxygenase 1, together with increased secretion of proinflammatory cytokines, including interleukin 1β (IL1β), IL6, and monocyte chemoattractant protein-1. Both Nrf2 overexpression and Nrf2 activator dimethyl fumarate (DMF...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Our lab previously published a genome-wide association study (GWAS) and meta-analysis to search for common alleles that contribute to risk of Alopecia Areata (AA), and identified genomic regions harboring potential susceptibility genes. One candidate susceptibility gene expressed in the hair follicle (HF) in AA is peroxiredoxin 5 (PRDX5) (p= 8.7*10-14), which is also a susceptibility gene in Crohn ’s disease, sarcoidosis, and psoriasis. PRDX5 is a member of the peroxiredoxin family of antioxidant enzymes crucial for regulating oxidative stress, which causes disruption in redox potentials that extend to the endoplasmi...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research
More News: Alopecia | Alopecia Areata | Antidoxidants | Crohn's Disease | Dermatology | Genetics | Psoriasis | Sarcoidosis | Skin | Study