Old T Cells Interfer(on) with Neurogenesis.
Old T Cells Interfer(on) with Neurogenesis.
Trends Immunol. 2019 Aug 15;:
Authors: Rustenhoven J, Herz J, Kipnis J
Abstract
Adult neurogenesis plays an important role in brain function and declines with aging. A recent report demonstrates clonal T cell expansion within neurogenic niches of the aged brain, impairing neurogenesis through IFNγ signaling (Dulken et al.,Nature, 2019). These results highlight T cells as important contributors to and potential therapeutic targets for age-related brain dysfunction.
PMID: 31422900 [PubMed - as supplied by publisher]
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Rustenhoven J, Herz J, Kipnis J Tags: Trends Immunol Source Type: research