Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism

Conclusion and Implications: Midkine is elevated in human and porcine plasma after multiple trauma, affecting the functionality and metabolism of human cardiomyocytes in vitro. If the application of CytoSorb300 filtration for patients after multiple trauma is a promising therapeutic approach to prevent post-traumatic cardiac dysfunction requires further examination.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Publication date: Available online 19 September 2019Source: Brain, Behavior, and ImmunityAuthor(s): Yinghua Peng, Xiaozheng Zhang, Tianshu Zhang, Peter M. Grace, Hongyuan Li, Yibo Wang, Hang Li, Hongqian Chen, Linda R. Watkins, Mark R. Hutchinson, Hang Yin, Xiaohui WangAbstractThere is growing interest in drug repositioning to find new therapeutic indications for drugs already approved for use in people. Lovastatin is an FDA approved drug that has been used clinically for over a decade as a lipid-lowering medication. While lovastatin is classically considered to act as a hydroxymethylglutaryl (HMG)-CoA reductase inhibitor,...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Conclusion1H-NMR based metabolomics and molecular docking provided the insights for the synergistic mechanisms and the potential active compounds of NZN in treating cerebral trauma. However, the bioactive compounds and their synergistic effect need to be further validated.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 September 2019Source: Materials Today: ProceedingsAuthor(s): Ekaterina Potapova, Ekaterina DmitrievaAbstractInvestigated influence of a metakaolin on processes of hydration and curing of a Portland cement. It has been shown that in the presence of metakaolin the rate of hydration and hardening of the cement are changed. The metakaolin is connected by Ca(OH)2, allocated at hydration of an alite, in hydroaluminates of calcium and poorly the kristallichny of hydrosilicates of calcium of various basicity. The additive of not modified metakaolin promotes formation of the low-main HSC (C/S...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Conclusion: We identified the physicians' prescription patterns of antihypertensive drugs for treatment-naïve patients. The findings of this study can lead to a rational, evidence-based, and cost-effective improvement of prescription patterns in newly diagnosed hypertensive patients. PMID: 31534797 [PubMed]
Source: International Journal of Hypertension - Category: Cardiology Tags: Int J Hypertens Source Type: research
Authors: Knuth CA, Andres Sastre E, Fahy NB, Witte-Bouma J, Ridwan Y, Strabbing EM, Koudstaal MJ, van de Peppel J, Wolvius EB, Narcisi R, Farrell E Abstract n tissue engineering, endochondral ossification (EO) is often replicated by chondrogenically differentiating mesenchymal stromal cells (MSCs) in vitro and achieving bone formation through in vivo implantation. The resulting marrow-containing bone constructs are promising as a treatment for bone defects. However, limited bone formation capacity has prevented them from reaching their full potential. This is further complicated since it is not fully understood how...
Source: European Cells and Materials - Category: Cytology Tags: Eur Cell Mater Source Type: research
By DAVE LEVIN, MD The 2019 Health 2.0 conference just wrapped up after several days of compelling presentations, panels, and networking. As in the past, attendees were a cross section of the industry: providers, payers, health IT (HIT) companies, investors, and others who are passionate about innovation in healthcare. Tech-enabled Services One of the more refreshing themes of the conference was an emphasis on how health IT can enable the delivery of services. This is a welcome perspective as too often organizations believe that simply deploying technology will solve their problems. In my 30+ years in healthcare, I...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Data Health 2.0 Health Tech Health Technology Start-Ups Burnout Datica Dave Levin health innovation Health IT tech-enabled services Source Type: blogs
In this study, we hypothesized that preoperative pregabalin reduces inhaled isoflurane requirements. METHODS: We have investigated the effectiveness of preoperative oral pregabalin 150 mg in women undergoing elective open total abdominal hysterectomy under general anesthesia. A prospective, randomized, double-blind, controlled study was conducted in a university hospital. The study included 50 women (18-60 yrs.), ASA I or II, admitted for abdominal hysterectomy under general anesthesia. Exclusion criteria were allergy to pregabalin; calcium channel blockers, antiepileptic drugs, antidepressant drugs, any analgesics, se...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Effects of Solution pH and Ions on Suicidal Germination of Bacillus subtilis Spores Induced by Medium High Temperature-Medium High Hydrostatic Pressure Treatment. Biocontrol Sci. 2019;24(3):167-172 Authors: Morimatsu K, Nakaura Y, Inaoka T, Kimura K, Yamamoto K Abstract Spores of Bacillus subtilis suspended in water or aqueous solution of NaCl, CaCl2, sodium lactate, or calcium lactate at pH 4 - 7 was subjected to spore inactivation by simultaneous combination of medium high hydrostatic pressure (MHHP; 100 MPa) treatment for germination and medium high temperature (MHT; 65℃) treatment for p...
Source: Biocontrol Science - Category: Microbiology Tags: Biocontrol Sci Source Type: research
Authors: Sun JJ, Tang L, Zhao XP, Xu JM, Xiao Y, Li H Abstract Background and Objective: Diabetic neuropathic pain (DNP) is a common complication associated with diabetes. Currently, its underlying pathomechanism remains unknown. Studies have revealed that the recruitment of blood monocyte-derived macrophages (MDMs) to the spinal cord plays a pivotal role in different models of central nervous system injury. Therefore, the present study aimed at exploring the infiltration and function of MDMs in DNP using a mice model. Methods: Diabetes was induced using streptozotocin in male A/J mice. Mechanical withdrawal th...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
In this study, 14 S100 cDNA sequences were determined in zebrafish and their genomic organizations confirmed. Re-analyzing the gene synteny of the S100 loci identified two major S100 loci in Chr16 and Chr19 which share remarkable conservation with the S100 locus in human Chr1, suggesting they may have evolved from a single locus during the teleost specific whole genome duplication event. It appears that the homologues of human S100G and S100P have been lost in zebrafish. Expression analysis reveals that S100W, ICN1 and ICN2 are markedly expressed in embryos. Further, the transcripts of S100 genes are relatively abundant in...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
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