Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism

Conclusion and Implications: Midkine is elevated in human and porcine plasma after multiple trauma, affecting the functionality and metabolism of human cardiomyocytes in vitro. If the application of CytoSorb300 filtration for patients after multiple trauma is a promising therapeutic approach to prevent post-traumatic cardiac dysfunction requires further examination.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research