Fabrication and biological activity of polycaprolactone/phlorotannin endotracheal tube to prevent tracheal stenosis: An in vitro and in vivo study

This study demonstrates that an endotracheal tube coated with phlorotannin, which is present in extracts of the brown algaEcklonia cava, can prevent tracheal stenosis in a rabbit model. An in vitro study shows that phlorotannin inhibits proliferation of human tracheal fibroblasts treated with transforming growth factor β1. Phlorotannin‐coated endotracheal tubes show steady release of phlorotannin for up to 7 days, and removal of the tube 1 week after insertion reveals a reduction in both fibrogenesis and thickening of tracheal submucosa. Western blot analysis of tracheal tissues after removal of the phlorotanni n‐coated tube shows decreased protein expression levels of phenotypic markers of fibrosis such as collagen type I and α‐smooth muscle actin. The ability of phlorotannin‐coated endotracheal tube to prevent tracheal stenosis caused by endotracheal intubation indicates that phlorotannin may be c onsidered as a candidate biomaterial for coating the cuff of endotracheal tubes to prevent tracheal stenosis.

Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - August 6, 2019 Category: Materials Science Authors: Hyoung Shin Lee, Min ‐Seon Jeong, Seok‐Chun Ko, Seong‐Yeong Heo, Hyun Wook Kang, Sung Won Kim, Chi Woo Hwang, Kang Dae Lee, Chulho Oak, Min Jung Jung, Junghwan Oh, Won Sun Park, Il‐Whan Choi, Won‐Kyo Jung Tags: ORIGINAL RESEARCH REPORT Source Type: research