Biophysical and microstructural changes of swelling cornea caused by endothelial cells damage.

Biophysical and microstructural changes of swelling cornea caused by endothelial cells damage.
Physiol Res. 2019 Aug 19;
Authors: He F, Liu J, Ye P, Wu J, Liang G, Xu W
Abstract
Biophysical properties and microstructural changes of swelling cornea which caused by endothelial cells damage will be evaluated. Swelling cornea models were established by endothelial cells damage in 114 Sprague Dawley rats. Relative gray value, swelling rate and light transmittance were measured to evaluated the biophysical properties and microstructure changes were observed by transmission electron microscopy. Relative gray value decreased while swelling rate rose along with time and both of them reached relative stability after 7 days. Light transmittance showed a decline trend with time even after coreal thickness had reached stable stage. Observed by transmission electron microscopy, interfibrillar distance increased, fewer proteoglycans coating appeared and remnants proteoglycan branches became thinner and longer in 7 days. Diameter of fibrils didn't change obviously with time. In cornea edema models caused by endothelial cells damage, the changes of biophysical property and the microstructure can help us evaluate corneal edema accurately and objectively.
PMID: 31424248 [PubMed - as supplied by publisher]

Source: Physiological Research - August 18, 2019 Category: Physiology Authors: He F, Liu J, Ye P, Wu J, Liang G, Xu W Tags: Physiol Res Source Type: research