Intracerebroventricular endothelin receptor-A blockade in rats decreases phase-II ventricular tachyarrhythmias during acute myocardial infarction.

We examined ventricular tachyarrhythmias after endothelin receptor-A blockade in the brain of Wistar rats with acute myocardial infarction. For this aim, BQ-123 (n=6) or phosphate-buffered saline (n=6) were injected intracerebroventricularly. After 10 min, the left coronary artery was ligated, followed by implantation of telemetry transmitters. Electrocardiography and voluntary activity (as a surrogate of acute left ventricular failure) were continuously monitored for 24 h. Infarct-size was similar in the two groups. There were fewer episodes of ventricular tachyarrhythmias of shorter average duration in treated rats, leading to markedly shorter total duration (12.3+/-8.9 s), when compared to controls (546.2+/-130.3 s). Voluntary activity increased in treated rats during the last hours of recording, but bradyarrhythmic episodes were comparable between the two groups. Endothelin receptor-A blockade in the brain of rats decreases the incidence of ventricular tachyarrhythmias post-ligation, without affecting bradyarrhythmic episodes. These findings call for further research on the pathophysiologic role of endothelin during acute myocardial infarction. PMID: 31424250 [PubMed - as supplied by publisher]
Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research

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AbstractBackgroundSympathetic neural activation plays a key role in the incidence and maintenance of acute myocardial infarction (AMI) induced ventricular arrhythmia (VA). Furthermore, previous studies showed that AMI might induce microglia and sympathetic activation and that microglial activation might contribute to sympathetic activation. Recently, studies showed that light emitting diode (LED) therapy might attenuate microglial activation. Therefore, we hypothesized that LED therapy might reduce AMI ‐induced VA by attenuating microglia and sympathetic activation.MethodsThirty anesthetized rats were randomly divided in...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ EXPERIMENTAL Source Type: research
Alterations in Maternal–Fetal Heart Rate Coupling Strength and Directions in Abnormal Fetuses Ahsan H. Khandoker1*, Steffen Schulz2, Haitham M. Al-Angari1, Andreas Voss2 and Yoshitaka Kimura3,4 1Department of Biomedical Engineering, Healthcare Engineering Innovation Center, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates 2Institute of Innovative Health Technologies IGHT, Ernst-Abbe-Hochschule, Jena, Germany 3Institute of International Advanced Interdisciplinary Research, Tohoku University School of Medicine, Sendai, Japan 4Department of Gynecology and Obstetrics, Tohoku Universi...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In this study, we used HUT as the means to provide an all-encompassing assessment of cardiac and/or peripheral autonomic function in normal controls, SCD subjects and non-SCD subjects with chronic anemia. We hypothesized that by identifying different categories of HUT response among these subjects, we would be able to isolate the autonomic phenotypes that might place SCD subjects at increased risk for microvascular occlusion and VOC. We then employed the causal modeling approach, which utilizes signal analysis and system identification techniques, to probe and disentangle the functional mechanisms involved in the cardiovas...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study only analyzed the PRQ phases that showed a constant PRQ over a specific period (frequency coupling) and also a phase entrainment between HR and RR (phase coupling) during this time. During sleep, a complex correlation between the HR and the RR is evident with the PRQ capturing one specific aspect. In a study investigating the N-rs-PRQ with a detailed division of the sleep stages (five stages), Zerm et al. (2008) showed that there is a positive correlation between the N-rs-PRQ and the sleep depth, i.e., the higher the depth of sleep, the lower the N-rs-PRQ. In this study, sleep depth was defined according to...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
CONCLUSIONS CSAD can suppress LSG neural activity, hence enhance the electrophysiological stability and protect the heart from AMI-triggered VAs. PMID: 30877783 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Periodic Repolarization Dynamics (PRD) is a novel electrocardiographic phenomenon that refers to sympathetic-activity associated low-frequency modulations of cardiac repolarization. Retrospective post myocardial infarction (MI) studies revealed that increased PRD indicates increased risk for subsequent death.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
Periodic repolarization dynamics (PRD) is a novel electrocardiographic phenomenon that refers to sympathetic activity –associated low-frequency modulations of cardiac repolarization. Retrospective post–myocardial infarction (MI) studies revealed that increased PRD indicates an increased risk of subsequent death.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
Abstract A 53-year-old female athlete with spontaneous coronary artery dissection, acute myocardial infarction, and infrarenal abdominal aortic dissection enrolled in a 6-week cardiovascular rehabilitation (CR) program. During CR sessions, the patient performed a combination of aerobic, resistance training, and core activities. In the final CR session, the patient performed reflex activities and the forced Valsalva maneuver. The patient's electrocardiogram, blood pressure, heart rate, and transient change in blood pressure over time were continuously monitored and recorded. The patient completed CR without negativ...
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
Lung cancer subjects undergo fatigue because of chronic stress, which affects their autonomic nervous system activity. The appearance of pseudo-myocardial infarction and T-wave inversion with no clinical symptoms were also detected in lung cancer condition. The present work aims to identify any variation in electrocardiogram (ECG) of lung cancer subjects in comparison with that of healthy controls. The lead II ECG (band-pass filtered from 0.5 to 35 Hz and sampled at 200 Hz) was recorded for 5 minutes using MP45 (Biopac System Inc, Goleta, CA) from 110 consecutive lung cancer subjects and 30 healthy controls in supine posit...
Source: Journal of Clinical Engineering - Category: Medical Devices Tags: Feature Articles Source Type: research
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Behavioral Health Exercise and Fitness Prevention Source Type: blogs
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