Insulin-like growth factor axis in pregnancy and gestational diabetes mellitus.

Insulin-like growth factor axis in pregnancy and gestational diabetes mellitus. Physiol Res. 2019 Aug 19; Authors: Anderlová K, Cinkajzlová A, Šimják P, Kloučková J, Kratochvílová H, Lacinová Z, Kaválková P, Krejčí H, Mráz M, Pařízek A, Haluzík M, Kršek M Abstract The insulin-like growth factor (IGF) is involved in the regulation of growth and metabolism. The aim of this study was to determine selected parameters of IGF system at systemic and local levels [subcutaneous (SAT) and visceral adipose tissue (VAT)] to assess its possible role in gestational diabetes mellitus (GDM). 37 pregnant women (21 with GDM and 16 without GDM) and 15 age-matched non-pregnant females were included in the study. Blood samples were taken in 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. SAT and VAT samples were obtained during delivery or surgery. Compared with non-pregnant women, serum IGF-1 and IGFBP-3 were increased in both groups of pregnant women. IGF-2 was elevated only in GDM women from 36 weeks of gestation culminating 6 months after delivery (p=0.003). Serum IGFBP-3 was increased and IGFBP-4 decreased in GDM women vs. pregnant women without GDM during the whole study (IGFBP-3: p
Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research

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Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
This study aimed to evaluate the reproducibility of three BIA instruments in pregnancy and analyse the relationship between the body composition and the GDM risk. Methods: A prospective cohort (n = 117) of women with singleton pregnancies participating in the Microbiome Understanding in Maternity Study (MUMS) at St. George Hospital, Sydney, Australia. Anthropometric measurements and BIA body composition were measured at ≤13 weeks (T1), 20-24 weeks (T2), and 32-36 weeks (T3) of gestation. Body fat percentage (BFP), total body water (TBW), and impedance were estimated by three BIA instruments: Bodystat 1...
Source: Journal of Obesity - Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research
Background and objective: The maternal glucose-insulin axis is central for metabolic adaptations required for a healthy pregnancy. Metabolic changes in obese mothers in early pregnancy have been scantly described. Here we characterized the glucose-insulin axis in the first trimester of human pregnancy and assessed the effect of maternal obesity and fat mass.Methods: In this cross-sectional study, maternal blood samples (N = 323) were collected during voluntary pregnancy termination (gestational age 4+0–11+6 weeks) after overnight fasting. Smokers (N = 198) were identified by self-report and serum cotinine levels (ELI...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
AbstractAimsFew studies have assessed the prevalence of diabetes and hypertension among pregnant women in China after the implementation of universal two-child policy. Therefore, the aim of the study was to determine the prevalence of diabetes and hypertension from 2016 to 2018 among pregnant women in Jiangsu, China, after the policy implementation.MethodsWe analysed data from pregnant women who delivered their neonates between 2016 and 2018 in the Northern Jiangsu People ’s Hospital. All pregnant women irrespective of their gestation weeks underwent oral glucose intolerance tests in a fasting state.ResultsA total of...
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
Endometrial polyps embedded in the fetal membranes have only rarely been described. A review of the English literature showed only one abstract describing this occurrence and to the best of our knowledge, there have been no other publications of this entity. Herein we present a case of a 37-yr-old woman with a history prior abortion and complicated pregnancy (type 2 diabetes mellitus and preeclampsia) who delivered by cesarean section. Although the placenta did not show hypertensive vasculopathic changes or other pathologic findings, an endometrial polyp embedded within the fetal membranes was present. Recognition of this ...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: ONLINE ARTICLE: CASE REPORT Source Type: research
Conditions:   Weight Loss;   Gestational Diabetes Interventions:   Other: PAIGE2 lifestyle intervention;   Other: Standard care Sponsors:   Belfast Health and Social Care Trust;   Northern Health and Social Care Trust;   South Eastern Health and Social Care Trust;   Interreg;   Our Lady of Lourdes Hospital, Drogheda;   Sligo General Hospital;   Letterkenny University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Women with gestational diabetes mellitus (GDM) have a higher risk of cesarean delivery (CD) than glucose-tolerant women. The aim of this study was to develop and validate a risk score for predicting primary CD...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
Although physical activity (PA) in pregnancy benefits most women, not much is known about pregnancy-related changes in PA and its association with gestational diabetes mellitus (GDM) risk. The aim of this stud...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
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Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
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Source: Primary Care Diabetes - Category: Primary Care Authors: Source Type: research
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