Analysis of cellular and soluble profiles in QuantiFERON nonconverters, converters, and reverters in the Gambia

ConclusionsOur results provide insight into the underlying mechanisms of resistance to sustainedMycobacterium tuberculosis infection.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research

Related Links:

We describe demographic, socioeconomic and clinical characteristics of patients randomized to the same-day initiation arm for both studies. RESULTS AND DISCUSSION: A total of 240 and 296 participants were enrolled in Kenya and South Africa. The majority were female (59% and 64% respectively), with a median age of 35 years. In both countries, most subjects were newly diagnosed with HIV on the day of enrolment (62%, 55%), believed they already had adequate knowledge to begin ART (78%, 68%), and preferred to start ART immediately (same-day) (98% in both countries). About 40% of all patients had at least one symptom r...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Publication date: 14–20 September 2019Source: The Lancet, Volume 394, Issue 10202Author(s): Anja Reuter, Jennifer Hughes, Jennifer FurinSummaryChildren bear a substantial burden of suffering when it comes to tuberculosis. Ironically, they are often left out of the scientific and public health advances that have led to important improvements in tuberculosis diagnosis, treatment, and prevention over the past decade. This Series paper describes some of the challenges and controversies in paediatric tuberculosis, including the epidemiology and treatment of tuberculosis in children. Two areas in which substantial challeng...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 14–20 September 2019Source: The Lancet, Volume 394, Issue 10202Author(s): Christoph Lange, Keertan Dheda, Dumitru Chesov, Anna Maria Mandalakas, Zarir Udwadia, C Robert HorsburghSummaryDrug-resistant tuberculosis is a major public health concern in many countries. Over the past decade, the number of patients infected with Mycobacterium tuberculosis resistant to the most effective drugs against tuberculosis (ie, rifampicin and isoniazid), which is called multidrug-resistant tuberculosis, has continued to increase. Globally, 4·6% of patients with tuberculosis have multidrug-resistant tuberculos...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: 14–20 September 2019Source: The Lancet, Volume 394, Issue 10202Author(s): The Lancet
Source: The Lancet - Category: General Medicine Source Type: research
The original version of this article unfortunately contained a mistake. The affiliation of Fariba Ghorbani should be Tracheal Diseases Research Center (TDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionHigher expression levels of miR-155 suggest potential roles of these miRNA in EsxA-dependent immune subversion.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
We present the case of a 46-year-old Caucasian male, affected by ulcerative colitis, who developed tuberculous pleurisy during immunosuppressive therapy; despite proper therapy, worsening of the radiological findings was observed. The case was discussed among an online group of Italian physicians and diagnosis of immune reconstitution inflammatory syndrome (IRIS) tuberculosis was established. Therapy was continued and full recovery was obtained. IRIS is a syndrome initially described during opportunistic infections in HIV infected after being placed in anti-retroviral therapy. It reveals itself through a wide variety of ma...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Authors: Gupta N, Mahendran AJ, Chakrabarti S, Agrawal S Abstract A 28-year-old male was admitted for breathlessness, haemoptysis, fever and fatigue. The patient had occupational exposure to silica dust. Arterial blood gas test ABG revealed hypoxemic respiratory failure. Chest CT demonstrated ground glass opacities with interlobular septal thickening and small centrilobular nodules with patchy areas of consolidation in bilateral lungs. He was mechanically ventilated for refractory hypoxemia. The treatment with cyclophosphamide and methylprednisolone lead to recovery and extubation. The final diagnosis was diffuse a...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Condition:   Diagnosis of Tuberculosis in People Living With HIV Intervention:   Device: Fujifilm SILVAMP TB LAM Sponsors:   Foundation for Innovative New Diagnostics, Switzerland;   Centre for Infectious Disease Research in Zambia;   Infectious Diseases Institute, Uganda;   Malawi-Liverpool-Wellcome Trust Clinical Research Programme;   Swiss TPH, Switzerland;   Ifakara Health Institute, Tanzania;   University of Cape Town;   Viet Tiep Hospital, Vietnam; &...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: The use of DTG-based ART regimens in patients coinfected with TB and HIV lead to favorable TB and HIV treatment outcomes, comparable to those achieved with alternative ART regimens. Our results provide reassurance to TB and HIV programs about the overall programmatic concomitant use of these first-line treatment regimens for the management of HIV and TB coinfected patients.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Rapid Communication Source Type: research
More News: Allergy & Immunology | Gambia Health | Study | Tuberculosis