Mitochondria and autophagy dysfunction in glucocorticoid-induced ocular hypertension/glaucoma mice model.
Conclusion: Dex-Ace administration decreased RGCs and changed TM ultrastructure, mimicking hallmarks of human glucocorticoid-induced glaucoma (GIG). In addition, mitochondria and autophagy dysfunction suggested abnormal energy metabolism in TM cells, which warranted further study to fully elucidate the pathogenesis of GIG.
PMID: 31425668 [PubMed - as supplied by publisher]
Source: Current Eye Research - Category: Opthalmology Authors: Zeng W, Wang W, Wu S, Zhu X, Zheng T, Chen X, Ren J, Gong Y, Ke M Tags: Curr Eye Res Source Type: research
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