High proportion of immature oocytes in a cohort reduces fertilization, development, pregnancy and live birth rates following ICSI

ConclusionsA high proportion of immature sibling oocytes in the retrieved cohort affects the fertilization rate and embryo developmental competence of MII inseminated oocytes, clinical pregnancy and live birth rates, suggesting that, in addition to nuclear maturity, ooplasmic and membrane maturity are required for developmental competence of MII oocytes. These findings may provide guidance toward ovarian stimulation protocols aimed at achieving a greater proportion of MII oocytes, leading to higher fertilization rates and better pregnancy outcomes.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research