Antibodies to neuronal surface proteins in Tourette Syndrome: lack of evidence in a European paediatric cohort.

Antibodies to neuronal surface proteins in Tourette Syndrome: lack of evidence in a European paediatric cohort. Brain Behav Immun. 2019 Aug 16;: Authors: Baglioni V, Coutinho E, Menassa DA, Giannocaro MP, Jacobson L, Buttiglione M, Petruzzelli O, Cardona F, Vincent A, EMTICS collaborative group Abstract In Tourette Syndrome (TS) a role for autoantibodies directed against neuronal proteins has long been suspected, but so far results are still inconsistent. The aim of this study was to look for antibodies to specific or undefined neuronal proteins that could be involved in the aetiology of the disease. Sera from children with Tourette syndrome or another chronic tic disorder (TS/TD), collected as part of the longitudinal European Multicentre Tics in Children Study, were investigated. Participants included 30 siblings of patients with TS/TD prior to developing tics (preclinical stage) and the same children after the first tic onset (onset), and 158 patients in the chronic phase undergoing an acute relapse (exacerbation). Presence of antibodies binding to rodent brain tissue was assessed by immunohistology on rat brain sections and by immunofluorescent staining of live hippocampal neurons. Live cell-based assays were used to screen for antibodies to NMDAR, CASPR2, LGI1, AMPAR and GABAAR. Immunohistology indicated evidence of antibodies reactive with brain tissue, binding mainly to the hippocampus, the basal ganglia or the cerebellum in 2...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research