Scientists confirm transmission of influenza A H7N9 from birds to people

Virus showing signs of mammal adaptation, raising possibility of person to person infectionRelated items from OnMedicaExperts issue warning over bird flu resurgence Coronavirus can spread between peopleControversial avian flu studies can be publishedUK population took fewest steps to prevent spread of swine fluClimate change may increase flu severity
Source: OnMedica Latest News - Category: UK Health Source Type: news

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ConclusionsThis Phase I trial showed the MDCK-derived H5N1 candidate vaccine is safe and immunogenic. The source of RBCs has a significant impact on the measurement of HAI titers (ClinicalTrials.gov number: NCT01675284.).
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
CONCLUSION: ANE is a distinctive type of acute encephalopathy with diverse clinical spectrum. Even though the diagnostic criteria are available, they might not be watertight. In addition, treatment options are still limited. Further studies for better outcome are needed. PMID: 31099193 [PubMed - in process]
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research
Publication date: Available online 17 May 2019Source: Preventive MedicineAuthor(s): Jessica L. Gleason, Amelia Jamison, Vicki S. Freimuth, Sandra Crouse QuinnAbstractRacial disparities in influenza vaccination persist between African American and White adults. It is critical to explore the reasons behind this disparity, which may be linked to the use of “folk” or home remedies for illness prevention and treatment. For this study, The GfK Group was contracted to conduct a nationally-representative survey (n = 819 African American and 838 White respondents). Respondents were asked about behaviors, attitudes, ...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: 16 May 2019Source: Cell, Volume 177, Issue 5Author(s): Sandhya Bangaru, Shanshan Lang, Michael Schotsaert, Hillary A. Vanderven, Xueyong Zhu, Nurgun Kose, Robin Bombardi, Jessica A. Finn, Stephen J. Kent, Pavlo Gilchuk, Iuliia Gilchuk, Hannah L. Turner, Adolfo García-Sastre, Sheng Li, Andrew B. Ward, Ian A. Wilson, James E. CroweSummaryHere, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A viruses. Structural characterization of FluA-20 with H1 and H3 he...
Source: Cell - Category: Cytology Source Type: research
Publication date: 16 May 2019Source: Cell, Volume 177, Issue 5Author(s): Akiko Watanabe, Kevin R. McCarthy, Masayuki Kuraoka, Aaron G. Schmidt, Yu Adachi, Taishi Onodera, Keisuke Tonouchi, Timothy M. Caradonna, Goran Bajic, Shengli Song, Charles E. McGee, Gregory D. Sempowski, Feng Feng, Patricia Urick, Thomas B. Kepler, Yoshimasa Takahashi, Stephen C. Harrison, Garnett KelsoeSummaryVaccines to generate durable humoral immunity against antigenically evolving pathogens such as the influenza virus must elicit antibodies that recognize conserved epitopes. Analysis of single memory B cells from immunized human donors has led u...
Source: Cell - Category: Cytology Source Type: research
Publication date: 16 May 2019Source: Cell, Volume 177, Issue 5Author(s): Yan Wu, George F. GaoA universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host &Microbe article, three studies identify broad protective epitopes in the hemagglutinin head domain that are exposed by trimer “breathing.”
Source: Cell - Category: Cytology Source Type: research
Yao-Wei Huang Porcine deltacoronavirus (PDCoV) causes severe diarrhea and vomiting in affected piglets. The aim of this study was to establish the basic, in vitro characteristics of the life cycle such as replication kinetics, cellular ultrastructure, virion morphology, and induction of autophagy of PDCoV. Time-course analysis of viral subgenomic and genomic RNA loads and infectious titers indicated that one replication cycle of PDCoV takes 5 to 6 h. Electron microscopy showed that PDCoV infection induced the membrane rearrangements with double-membrane vesicles and large virion-containing vacuoles. The convoluted memb...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Abstract PURPOSE OF REVIEW: Incidence of community-acquired respiratory viruses (CARVs) after lung transplantation (LTx) is 10-68 cases per 100 patient-years. Infected patients may develop graft failure and there seems to be an association between CARV infection and development of chronic lung allograft dysfunction (CLAD). This review summarizes the impact of CARV infection after LTx and potential treatment strategies. RECENT FINDINGS: Detection rate of CARV depends on diagnostic methods. CARV infections after LTx are reported more frequently probably attributed to improved diagnostic methods, especially nucl...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
CONCLUSION: Using NAAT for the detection of respiratory pathogens in adults presenting with SCD slightly improved the microbiological diagnostic of febrile ACS, although respiratory infections are not the main etiological factor. PMID: 31088757 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
From 9 through 30 April 2019, the National International Health Regulations (IHR) Focal Point of Saudi Arabia reported nine additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including three deaths.
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
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