Scientists confirm transmission of influenza A H7N9 from birds to people

Virus showing signs of mammal adaptation, raising possibility of person to person infectionRelated items from OnMedicaExperts issue warning over bird flu resurgence Coronavirus can spread between peopleControversial avian flu studies can be publishedUK population took fewest steps to prevent spread of swine fluClimate change may increase flu severity
Source: OnMedica Latest News - Category: UK Health Source Type: news

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The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.  Click arrow to play Download TWiV 520 (70 MB .mp3, 116 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology chronic kidney disease clinical trial HA stalk vaccine immunocompromised immunosufficient influenza kidney fibrosis parvovirus peptide tubulointerstitial nephropathy universal influenza vaccine viral viruses Source Type: blogs
r Lal Influenza still remains one of the most challenging diseases, posing a significant threat to public health. Host lipid rafts play a critical role in influenza A virus (IAV) assembly and budding, however, their role in polyvalent IAV host binding and endocytosis had remained elusive until now. In the present study, we observed co-localization of IAV with a lipid raft marker ganglioside, GM1, on the host surface. Further, we isolated the lipid raft micro-domains from IAV infected cells and detected IAV protein in the raft fraction. Finally, raft disruption using Methyl-β-Cyclodextrin revealed significant r...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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Source: Journal of Evolutionary Biology - Category: Biology Authors: Tags: Research Papers Source Type: research
In this study, we generated VLPs containing hemagglutinin (HA), neuraminidase (NA) or M1 proteins derived from the A/California/04/09. Mice were immunized intramuscularly with HA-M1, NA-M1 or M1 VLPs and protective immunity was evaluated by assessing lung virus loads against low (5LD50) or high (100LD50) lethal dose of homologous virus challenges. High levels of virus-specific serum IgG antibody responses were induced in mice after HA-M1 VLPs immunization, whereas low or no IgG antibody responses were detected from immunization with NA-M1 VLPs or M1 VLPs, independently. Mice that were immunized with HA-M1 VLPs showed below...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
ConclusionsThe current study indicates that a history of OSAS/CSAS, myocardial infarction and BMI > 30 might be related to ICU admission in influenza patients. Second, ICU patients develop more pulmonary co-infections. Last, (pre-existent) renal failure and diabetes mellitus are more often observed in non-survivors.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
Publication date: Available online 16 November 2018Source: Veterinary MicrobiologyAuthor(s): Xiaohong Xu, Cong Xue, Renfu Yin, Xinxin Liu, Junjiao Li, Yidong Fei, Zhe Liu, Jiaqi Mu, Yuhai Bi, Tobias Stoeger, Jing Qian, Zhuang DingAbstractNewcastle disease virus (NDV) and H9 subtype avian influenza virus (AIV) are two avian pathogens across the globe. Inasmuch as most poultry flocks worldwide are vaccinated with a live low-virulence or attenuated NDV vaccine, we embarked on the development of vaccine prototypes that would have dual specificities and would allow a single immunization against both avian influenza (AI) and New...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 16 November 2018Source: Veterinary MicrobiologyAuthor(s): Juanhua Liu, Xiaohui Mu, Xiaobo Wang, Haixia Huan, Qingqing Gao, Juan Chen, Peizhuang Qiao, Luyao Jiang, Song Gao, Xiufan LiuAbstractThe lambda red recombination system makes it suitable for screening virulence gene utility in avian pathogenic Escherichia coli (APEC) on account of its wide applicability, simplicity and high efficiency. In APEC E058 (O2 serogroup), there are two copies of the outer membrane protease (ompT) gene, compT encoding cOmpT that is located on the chromosome and pompT encoding pOmpT that is located on a ColV...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 16 November 2018Source: BiologicalsAuthor(s): Ismaila Shittu, Adeyinka J. Adedeji, Pam D. Luka, Olayinka O. Asala, Nancy M. Sati, Ijeoma O. Nwagbo, Chinonyerem N. Chinyere, Oluwadamilola O. Arowolo, Jolly A. Adole, Paulinus Emennaa, Paul A. Abdu, Tony M. JoannisAbstractGlobally, vaccines are used to prevent and control the menace of infectious diseases in livestock with some reported to be inadvertently contaminated with extraneous agents (EAs). With the aim of screening and characterizing for some selected EAs, 44 live viral poultry vaccines were randomly selected based on availability. ...
Source: Biologicals - Category: Biology Source Type: research
Avian ocular disease may be primary or a manifestation of systemic disease. Various infectious and noninfectious diseases have been reported to cause ocular pathology. Thorough physical examination and diagnostic testing are necessary to determine a treatment plan.
Source: Veterinary Clinics of North America: Exotic Animal Practice - Category: Veterinary Research Authors: Source Type: research
In conclusion, the identification and surveillance of influenza virus types and subtypes circulating in populations have importance both for epidemiological data and selection of vaccine strains. PMID: 25492660 [PubMed - indexed for MEDLINE]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
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